Mechanisms of Cross-protection by Influenza Virus M2-based Vaccines

Yu-Na Lee; Min-Chul Kim; Young-Tae Lee; Yu-Jin Kim; Sang-Moo Kang

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자료유형: 학술저널

저자정보: Yu-Na Lee (Georgia State University) Min-Chul Kim (Georgia State University) Young-Tae Lee (Georgia State University) Yu-Jin Kim (Georgia State University) Sang-Moo Kang (Georgia State University)

저널정보: 대한면역학회 Immune Network Immune Network Vol.15 No.5

발행연도: 2015.10

수록면: 213 - 221 (9page)

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Current influenza virus vaccines are based on strain-specific surface glycoprotein hemagglutinin (HA) antigens and effective only when the predicted vaccine strains and circulating viruses are well-matched. The current strategy of influenza vaccination does not prevent the pandemic outbreaks and protection efficacy is reduced or ineffective if mutant strains emerge. It is of high priority to develop effective vaccines and vaccination strategies conferring a broad range of cross protection. The extracellular domain of M2 (M2e) is highly conserved among human influenza A viruses and has been utilized to develop new vaccines inducing cross protection against different subtypes of influenza A virus. However, immune mechanisms of cross protection by M2e-based vaccines still remain to be fully elucidated. Here, we review immune correlates and mechanisms conferring cross protection by M2e-based vaccines. Molecular and cellular immune components that are known to be involved in M2 immune-mediated protection include antibodies, B cells, T cells, alveolar macrophages, Fc receptors, complements, and natural killer cells. Better understanding of protective mechanisms by immune responses induced by M2e vaccination will help facilitate development of broadly cross protective vaccines against influenza A virus.

#Influenza virus #M2e #Universal vaccine #Immune mechanism

INTRODUCTION
M2e ANTIBODIES AND ANTIGENIC BINDING PROPERTIES
IMPROVED CROSS PROTECTION BY HETEROLOGOUS M2e DOMAINS PRESENTED ON VIRUS-LIKE PARTICLES
MECHANISMS OF M2e-BASED VACCINES IN CONFERRING CROSS PROTECTION AGAINST INFLUENZA
SUPPLEMENTED VACCINATIONS WITH A REALISTIC GOAL OF CONFERRING BROADER CROSS PROTECTION
CONCLUSION
REFERENCES

참고문헌 (66)

참고문헌 신청

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