지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 153 - 158 (6page)
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Objectives : This study was designed to investigate how the size- and surface coating-dependent toxicity of silver nanoparticles (AgNPs) is influenced by the presence and absence of the chorion in an embryonic zebrafish assay.
Methods : Normal and dechorinated embryos were exposed to four different AgNPs, 20 or 110 nm in size, with polypyrrolidone (PVP) or citrate surface coatings in a standard zebrafish embryo medium (EM). This was then compared to a 62.5 μM calcium chloride (CaCl₂) solution where agglomeration was controlled.
Results : Embryonic toxicity in the absence of the chorion was greater than in its presence. The smaller 20 nm AgNPs were more toxic than the larger 110 nm AgNPs, regardless of the chorion and test media. However, surface coating affected toxicity, since PVPcoated AgNPs were more toxic than citrate-coated AgNPs; this was strongly affected by the presence of the chorion in both EM and CaCl₂.
Conclusions : Our results demonstrate the permeability function of the chorion on the size- and surface coating-dependent toxicity of AgNPs. Thereafter, careful experiment should be conducted to assess nanoparticle toxicity in zebrafish embryos.
Methods : Normal and dechorinated embryos were exposed to four different AgNPs, 20 or 110 nm in size, with polypyrrolidone (PVP) or citrate surface coatings in a standard zebrafish embryo medium (EM). This was then compared to a 62.5 μM calcium chloride (CaCl₂) solution where agglomeration was controlled.
Results : Embryonic toxicity in the absence of the chorion was greater than in its presence. The smaller 20 nm AgNPs were more toxic than the larger 110 nm AgNPs, regardless of the chorion and test media. However, surface coating affected toxicity, since PVPcoated AgNPs were more toxic than citrate-coated AgNPs; this was strongly affected by the presence of the chorion in both EM and CaCl₂.
Conclusions : Our results demonstrate the permeability function of the chorion on the size- and surface coating-dependent toxicity of AgNPs. Thereafter, careful experiment should be conducted to assess nanoparticle toxicity in zebrafish embryos.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (17)
참고문헌 신청
US Environmental Protection Agency / State of the science literature review: everything nanosilver and more
Hill AJ / 2005 / Zebrafish as a model vertebrate for investigating chemical toxicity / Toxicol Sci 86(1):6~19
Parng C / 2005 / In vivo zebrafish assays for toxicity testing / Curr Opin Drug Discov Devel 8(1):100~106
Howe K / 2013 / The zebrafish reference genome sequence and its relationship to the human genome / Nature 496(7446):498~503
Kim KT / 2013 / Integrating zebrafish toxicology and nanoscience for safer product development / Green Chem 15(4):872~880
Hill AJ / 2005 / Zebrafish as a model vertebrate for investigating chemical toxicity / Toxicol Sci 86(1):6~19
Parng C / 2005 / In vivo zebrafish assays for toxicity testing / Curr Opin Drug Discov Devel 8(1):100~106
Howe K / 2013 / The zebrafish reference genome sequence and its relationship to the human genome / Nature 496(7446):498~503
Kim KT / 2013 / Integrating zebrafish toxicology and nanoscience for safer product development / Green Chem 15(4):872~880
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UCI(KEPA) : I410-ECN-0101-2016-539-002083259