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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 347 - 354 (8page)
이용수
초록· 키워드
오류제보하기
Excess manganese (Mn) is neurotoxic. Increased manganese stores in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. We previously showed that the transport and neurotoxicity of manganese after intranasal instillation of the metal are altered in Hfe-deficient mice, a mouse model of the iron overload disorder hereditary hemochromatosis (HH). However, it is not fully understood whether loss of Hfe function modifies Mn neurotoxicity after ingestion. To investigate the role of Hfe in oral Mn toxicity, we exposed Hfe-knockout (Hfe<SUP>−/−</SUP>) and their control wild-type (Hfe<SUP>+/+</SUP>) mice to MnCl₂ in drinking water (5 mg/mL) for 5 weeks. Motor coordination and spatial memory capacity were determined by the rotarod test and the Barnes maze test, respectively. Brain and liver metal levels were analyzed by inductively coupled plasma mass spectrometry. Compared with the water-drinking group, mice drinking Mn significantly increased Mn concentrations in the liver and brain of both genotypes. Mn exposure decreased iron levels in the liver, but not in the brain. Neither Mn nor Hfe deficiency altered tissue concentrations of copper or zinc. The rotarod test showed that Mn exposure decreased motor skills in Hfe<SUP>+/+</SUP> mice, but not in Hfe<SUP>−/−</SUP> mice (p = 0.023). In the Barns maze test, latency to find the target hole was not altered in Mn-exposed Hfe+/+ compared with water-drinking Hfe<SUP>+/+</SUP> mice. However, Mn-exposed Hfe<SUP>−/−</SUP> mice spent more time to find the target hole than Mn-drinking Hfe<SUP>+/+</SUP> mice (p = 0.028). These data indicate that loss of Hfe function impairs spatial memory upon Mn exposure in drinking water. Our results suggest that individuals with hemochromatosis could be more vulnerable to memory deficits induced by Mn ingestion from our environment. The pathophysiological role of HFE in manganese neurotoxicity should be carefully examined in patients with HFE-associated hemochromatosis and other iron overload disorders.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Cotzias, G. C. / 1958 / Manganese in health and disease / Physiol. Rev. 38:503~532
Ye, Q. / 2015 / Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis / Environ. Toxicol. Pharmacol. 40:333~341
Chen, P. / 2015 / Manganese homeostasis in the nervous system / J. Neurochem 134:601~610
Zielhuis, R. L. / 1978 / Levels of lead and other metals in human blood:suggestive relationships, determining factors / Environ. Health Perspect. 25:103~109
Davis, C. D. / 1992 / Varying levels of manganese and iron affect absorption and gut endogenous losses of manganese by rats / J. Nutr. 122:1300~1308
Ye, Q. / 2015 / Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis / Environ. Toxicol. Pharmacol. 40:333~341
Chen, P. / 2015 / Manganese homeostasis in the nervous system / J. Neurochem 134:601~610
Zielhuis, R. L. / 1978 / Levels of lead and other metals in human blood:suggestive relationships, determining factors / Environ. Health Perspect. 25:103~109
Davis, C. D. / 1992 / Varying levels of manganese and iron affect absorption and gut endogenous losses of manganese by rats / J. Nutr. 122:1300~1308
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UCI(KEPA) : I410-ECN-0101-2016-513-002331441