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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Lung cancer is a leading cause of cancer-related death in the world. Smoking is definitely the most important risk factor for lung cancer. Radon (<SUP>222</SUP>Rn) is a natural gas produced from radium (<SUP>226</SUP>Ra) in the decay series of uranium (<SUP>238</SUP>U). Radon exposure is the second most common cause of lung cancer and the first risk factor for lung cancer in never-smokers.
Case–control studies have provided epidemiological evidence of the causative relationship between indoor radon exposure and lung cancer. Twenty-four case–control study papers were found by our search strategy from the PubMed database. Among them, seven studies showed that indoor radon has a statistically significant association with lung cancer. The studies performed in radon-prone areas showed a more positive association between radon and lung cancer. Reviewed papers had inconsistent results on the dose–response relationship between indoor radon and lung cancer risk.
Further refined case–control studies will be required to evaluate the relationship between radon and lung cancer. Sufficient study sample size, proper interview methods, valid and precise indoor radon measurement, wide range of indoor radon, and appropriate control of confounders such as smoking status should be considered in further case–control studies.
Case–control studies have provided epidemiological evidence of the causative relationship between indoor radon exposure and lung cancer. Twenty-four case–control study papers were found by our search strategy from the PubMed database. Among them, seven studies showed that indoor radon has a statistically significant association with lung cancer. The studies performed in radon-prone areas showed a more positive association between radon and lung cancer. Reviewed papers had inconsistent results on the dose–response relationship between indoor radon and lung cancer risk.
Further refined case–control studies will be required to evaluate the relationship between radon and lung cancer. Sufficient study sample size, proper interview methods, valid and precise indoor radon measurement, wide range of indoor radon, and appropriate control of confounders such as smoking status should be considered in further case–control studies.
목차
Abstract
Background
Literature search
Case-control studies that included both smokers and never-smokers
Case-control studies that included non-smokers only
Studies in radon-prone areas versus lower exposure areas
A dose-response relationship between indoor radon and lung cancer
Radon and lung cancer risk of histologic subtype
Future study design
Conclusions
References
참고문헌 (32)
참고문헌 신청
Hubaux R, Becker-Santos DD, Enfield KS, Lam S, Lam WL, Martinez VD. Arsenic, asbestos and radon: emerging players in lung tumorigenesis. Environ Health. 2012;11:89.
International Agency for Research on Cancer. Man-made mineral fibres and radon: summary of data reported and evaluation. IARC monographs, vol. 43 [Internet]; 1988.
Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Field RW, Klotz JB, Letourneau EG, Lynch CF, Lyon JI et al. Residential radon and risk of lung cancer: a combined analysis of 7 North American case–control studies. Epidemiology. 2005;16(2):137–45.
Wilcox HB, Al-Zoughool M, Garner MJ, Jiang H, Klotz JB, Krewski D, Nicholson WJ, Schoenberg JB, Villeneuve PJ, Zielinski JM. Case–control study of radon and lung cancer in New Jersey. Radiat Prot Dosimetry. 2008;128(2):169–79.
Yao SX, Lubin JH, Qiao YL, Boice Jr JD, Li JY, Cai SK, Zhang FM, Blot WJ. Exposure to radon progeny, tobacco use and lung cancer in a case–control study in southern China. Radiat Res. 1994;138(3):326–36.
International Agency for Research on Cancer. Man-made mineral fibres and radon: summary of data reported and evaluation. IARC monographs, vol. 43 [Internet]; 1988.
Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Field RW, Klotz JB, Letourneau EG, Lynch CF, Lyon JI et al. Residential radon and risk of lung cancer: a combined analysis of 7 North American case–control studies. Epidemiology. 2005;16(2):137–45.
Wilcox HB, Al-Zoughool M, Garner MJ, Jiang H, Klotz JB, Krewski D, Nicholson WJ, Schoenberg JB, Villeneuve PJ, Zielinski JM. Case–control study of radon and lung cancer in New Jersey. Radiat Prot Dosimetry. 2008;128(2):169–79.
Yao SX, Lubin JH, Qiao YL, Boice Jr JD, Li JY, Cai SK, Zhang FM, Blot WJ. Exposure to radon progeny, tobacco use and lung cancer in a case–control study in southern China. Radiat Res. 1994;138(3):326–36.
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UCI(KEPA) : I410-ECN-0101-2016-517-002741945