지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Background: According to US-EPA report, the use of pyrethrins and pyrethroids has increased during the past decade, and their area of use included not only in agricultural settings, but in commerce, and individual household. It is known that urinary 3-PBA, major metabolite of pyrethroid, have some associations with health effect in nervous and endocrine system, however, there’s no known evidence that urinary 3-PBA have associations with obesity.
Method: We used data of 3671 participants aged above 19 from the Korean National Environmental Health Survey in 2009–2011. In our analysis, multivariate piece-wise regression and logistic regression analysis were used to investigate the association between urinary 3-PBA (3-Phenoxybenzoic Acid) and BMI.
Result: Log-transformed level of urinary 3-PBA had significantly positive association with BMI at the low-level range of exposure (p ＜ 0.0001), and opposite associations were observed at the high level exposure (p = 0.04) after adjusting covariates. In piece-wise regression analysis, the flexion point that changes direction of the associations was at around 4 ㎍/g creatinine of urinary 3-PBA. As quintiles based on concentration of urinary 3-PBA increased to Q4, the ORs for prevalence of overweight (BMI ≥ 23 ㎏/㎡) were increased, and the OR of Q5 was lower than that of Q4 (OR=1.810 for Q4; OR = 1.483 for Q5). In the analysis using obesity (BMI ≥ 25 ㎏/㎡) as outcome variable, significant associations were observed between obesity and quintiles of 3-PBA, however, there were no differences between the OR of Q5 and that of Q4 (OR = 1.659 for Q4; OR = 1.666 for Q5).
Conclusion: Our analysis suggested that low-level of pyrethroid exposure has positive association with BMI, however, there is an inverse relationship above the urinary 3-PBA level at 4 ㎍/g creatinine.
Method: We used data of 3671 participants aged above 19 from the Korean National Environmental Health Survey in 2009–2011. In our analysis, multivariate piece-wise regression and logistic regression analysis were used to investigate the association between urinary 3-PBA (3-Phenoxybenzoic Acid) and BMI.
Result: Log-transformed level of urinary 3-PBA had significantly positive association with BMI at the low-level range of exposure (p ＜ 0.0001), and opposite associations were observed at the high level exposure (p = 0.04) after adjusting covariates. In piece-wise regression analysis, the flexion point that changes direction of the associations was at around 4 ㎍/g creatinine of urinary 3-PBA. As quintiles based on concentration of urinary 3-PBA increased to Q4, the ORs for prevalence of overweight (BMI ≥ 23 ㎏/㎡) were increased, and the OR of Q5 was lower than that of Q4 (OR=1.810 for Q4; OR = 1.483 for Q5). In the analysis using obesity (BMI ≥ 25 ㎏/㎡) as outcome variable, significant associations were observed between obesity and quintiles of 3-PBA, however, there were no differences between the OR of Q5 and that of Q4 (OR = 1.659 for Q4; OR = 1.666 for Q5).
Conclusion: Our analysis suggested that low-level of pyrethroid exposure has positive association with BMI, however, there is an inverse relationship above the urinary 3-PBA level at 4 ㎍/g creatinine.
목차
Abstract
Background
Methods
Results
Discussion
Conclusions
References
참고문헌 (50)
참고문헌 신청
Grube A, Donaldson D, Kiely T, Wu L. Pesticides industry sales and usage. Washington, DC: US EPA; 2011.
Cha ES, Jeong M, Lee WJ. Agricultural pesticide usage and prioritization in South Korea. J Agromedicine. 2014;19(3):281–93. doi:10.1080/1059924X.2014. 917349. PubMed.
Vijverberg HP, van der Zalm JM, van den Bercken J. Similar mode of action of pyrethroids and DDT on sodium channel gating in myelinated nerves. Nature. 1982;295(5850):601–3.
Aldridge W. An assessment of the toxicological properties of pyrethroids and their neurotoxicity. CRC Crit Rev Toxicol. 1990;21(2):89–104.
Quiros-Alcala L, Mehta S, Eskenazi B. Pyrethroid pesticide exposure and parental report of learning disability and attention deficit/hyperactivity disorder in U.S. children: NHANES 1999-2002. Environ Health Perspect. 2014; 122(12):1336–42. doi:10.1289/ehp.1308031. PubMed PMID: 25192380, PubMed Central PMCID: PMC4256700.
Cha ES, Jeong M, Lee WJ. Agricultural pesticide usage and prioritization in South Korea. J Agromedicine. 2014;19(3):281–93. doi:10.1080/1059924X.2014. 917349. PubMed.
Vijverberg HP, van der Zalm JM, van den Bercken J. Similar mode of action of pyrethroids and DDT on sodium channel gating in myelinated nerves. Nature. 1982;295(5850):601–3.
Aldridge W. An assessment of the toxicological properties of pyrethroids and their neurotoxicity. CRC Crit Rev Toxicol. 1990;21(2):89–104.
Quiros-Alcala L, Mehta S, Eskenazi B. Pyrethroid pesticide exposure and parental report of learning disability and attention deficit/hyperactivity disorder in U.S. children: NHANES 1999-2002. Environ Health Perspect. 2014; 122(12):1336–42. doi:10.1289/ehp.1308031. PubMed PMID: 25192380, PubMed Central PMCID: PMC4256700.
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UCI(KEPA) : I410-ECN-0101-2016-517-002749012