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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.43 No.1
- 발행연도
- 2016.3
- 수록면
- 52 - 60 (9page)
이용수
초록· 키워드
오류제보하기
In animal reproduction, the quality of oocytes and embryos has been evaluated by the expression of specific molecules. Follistatin (FST), which was isolated from follicular fluid, binds and bio-neutralizes the TGF-β superfamily members. Previous studies using the bovine model showed FST could be an important molecular determinant of embryo developmental competence. However, the effect of FST treatment on porcine embryo developmental competence has not been established. In this study, the effect of exogenous FST on porcine embryo developmental competence was investigated during in vitro culture. FST (10 ng/ml) treatment induced a significant decrease in the rate of cell arrest at the 4-cell stage. The expression levels of DNA-methyltransferase 1 (DNMT1), histone deacetylase 1 (HDAC1), and histone deacetylase 2 (HDAC2) were decreased in 4-cell stage embryos. FST treatment also resulted in significant improvements in developmental competence of embryos in terms of blastocyst formation rate and OCT-4 mRNA levels, the latter being related to pluripotency. In conclusion, during in vitro culture, FST treatment significantly ameliorated 4-cell block during embryonic development and improved embryo developmental competence. Therefore, FST treatment may potentially have a functional role in porcine embryogenesis that is broadly applicable to enhance in vitro embryo development.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (29)
참고문헌 신청
Albano RM, Smith JC. 1994. Follistatin expression in ES and F9 cells and in preimplantation mouse embryos. TheInternational Journal of Developmental Biology 38:543547.
Balemans W, Van HW. 2002. Extracellular regulation of BMP signaling in vertebrates: A cocktail of modulators.Developmental Biology 250:231250.
Baroux C, Autran D, Gillmor CS, Grimanell D, Grossniklaus U. 2009. The maternal to zygotic transition in animals andplants. Cold Spring Harbor Symposia on Quantitative. Biology 73:89100.
Bettegowda A, Patel OV, Lee KB, Park KE, Salem M, Yao J. Ireland JJ, Smith GW. 2008. Identification of novel bovinecumulus cell molecular markers predictive of oocyte competence: functional and diagnostic implications. Biology ofReproduction 79:301309.
Findlay JK, Drummond AE, Dyson ML, Baillie AJ, Robertson DM, Ethier JF. 2002. Recruitment and development of thefollicle; the roles of the transforming growth factor-beta superfamily. Molecular and cellular endocrinology 191:3543.
Balemans W, Van HW. 2002. Extracellular regulation of BMP signaling in vertebrates: A cocktail of modulators.Developmental Biology 250:231250.
Baroux C, Autran D, Gillmor CS, Grimanell D, Grossniklaus U. 2009. The maternal to zygotic transition in animals andplants. Cold Spring Harbor Symposia on Quantitative. Biology 73:89100.
Bettegowda A, Patel OV, Lee KB, Park KE, Salem M, Yao J. Ireland JJ, Smith GW. 2008. Identification of novel bovinecumulus cell molecular markers predictive of oocyte competence: functional and diagnostic implications. Biology ofReproduction 79:301309.
Findlay JK, Drummond AE, Dyson ML, Baillie AJ, Robertson DM, Ethier JF. 2002. Recruitment and development of thefollicle; the roles of the transforming growth factor-beta superfamily. Molecular and cellular endocrinology 191:3543.
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UCI(KEPA) : I410-ECN-0101-2016-480-002738466