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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 101 - 108 (8page)
- DOI
- 10.15188/kjopp.2016.04.30.2.101
이용수
초록· 키워드
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This study is conducted to investigate vasorelaxant effect of Corni Fructus(CF) on rabbit carotid artery. To determine vasorelaxant effect of CF on rabbit carotid artery, arterial sections with intact or removed endothelium were used in this organ bath study. After being contracted by phenylephrine(PE), arterial sections were treated with CF extract in a dose-dependent manner. To identity its mechanism, the contracted arterial sections by PE were pretreated with indomethacin(IM), tetraethylammonium chloride(TEA), Nω-nitro-L-arginine(L-NNA) or methylene blue(MB) and 1.0 ㎎/㎖ CF extract. We also studied to confirm the effect on influx of extracellular calcium chloride(Ca<SUP>2+</SUP>) of the CF extract in rabbit carotid artery. To measure the cytotoxicity of the CF extract, cell viability of human umbilical vein endothelial cell(HUVEC) was measured by MTT assay. Generation of nitric oxide(NO) was also measured by Griess reagent. The arterial sections with intact endothelium were relaxed significantly by CF extract, but this effect was inhibited in the arterial sections with damaged endothelium. The vasorelaxant effect was inhibited significantly when arterial sections were pretreated with IM, TEA, L-NNA, MB. In Ca<SUP>2+</SUP>-free krebs solution, increasing of arterial contraction by Ca<SUP>2+</SUP> was also inhibited by CF significantly. The treatment of CF extract increased NO concentration in HUVEC. This study suggested that the vasorelaxant effect of CF extract would be related with endothelium derived relaxing factor(EDRF) such as NO, prostacyclin(PGI₂), endothelium derived hyperpolarization factor(EDHF).
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (74)
참고문헌 신청
Statistics Korea. 2014 Statistics on causes of death. p 1, 2015.
Ministry of Health and Welfare. 2012 National Health Statistics : National Health and Nutrition Examination Survey. 2013.
Kim, H.R., Son, H.G. Prevalence of Hypertension and Its Risk Factors among Aged 65 and over in Korea. Journal of Korean Biological Nursing Science 14(4):282-290, 2012.
Luscher T.F., Barton, M. Biology of the endothelium. clin cardiol 20(2):3-10, 1997.
Kinlat, S., Libby, P. Endothelial function and coronary artery disease. Curr Opin Lipidol 12: 383-389, 2001.
Ministry of Health and Welfare. 2012 National Health Statistics : National Health and Nutrition Examination Survey. 2013.
Kim, H.R., Son, H.G. Prevalence of Hypertension and Its Risk Factors among Aged 65 and over in Korea. Journal of Korean Biological Nursing Science 14(4):282-290, 2012.
Luscher T.F., Barton, M. Biology of the endothelium. clin cardiol 20(2):3-10, 1997.
Kinlat, S., Libby, P. Endothelial function and coronary artery disease. Curr Opin Lipidol 12: 383-389, 2001.
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