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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 247 - 252 (6page)
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초록· 키워드
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This study was conducted to investigate the occurrence of oxidative stress in the heart tissue of rats infected with Trypanosoma evansi. Rats were divided into 2 groups (A and B) with 12 animals each, and further subdivided into 4 subgroups (A1 and A2, 6 animals/each; and B1 and B2, 6 animals/each). Animals in the groups B1 and B2 were subcutaneously inoculated with T. evansi. Thiobarbituric acid reactive substances (TBARS), superoxide dismutase activity (SOD), glutathione S-transferase activity (GST), reduced glutathione activity (GSH), and non-protein thiols (NPSH) in the heart tissue were evaluated. At day 5 and 15 post-infection (PI), an increase in the TBARS levels and a decrease in the SOD activity (P<0.05) were observed. GSH and GST activities were decreased in infected animals at day 15 PI (P<0.05). Considering the proper functioning of the heart, it is possible that the changes in the activity of these enzymes involved in the oxidative stress may be related, at least in part, in the pathophysiology of rats infected with T. evansi.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[단행본] - Maudlin I / 2004 / The Trypanosomiases / CABI Publishing Co : 640 ~
[단행본] - Hoare CA / 1972 / The Trypanosomes of Mammals, a Zoological Monograph / Blackwell
[학술지(정기간행물)] - Baldissera MD / 2015 / Enzymatic activities linked to cardiac energy metabolism of Trypanosoma evansi-infected rats and their possible functional correlations to disease pathogenesis / Parasitology 142 : 1163 ~ 1170
[학술지(정기간행물)] - Betteridge DJ / 2000 / What is oxidative stress? / Metabolism 49 : 3 ~ 8
[학술지(정기간행물)] - Thannickal VJ / 2000 / Reactive oxygen species in cell signaling / Am J Physiol Lung Cell Mol Physiol 279 : 1005 ~ 1028
[단행본] - Hoare CA / 1972 / The Trypanosomes of Mammals, a Zoological Monograph / Blackwell
[학술지(정기간행물)] - Baldissera MD / 2015 / Enzymatic activities linked to cardiac energy metabolism of Trypanosoma evansi-infected rats and their possible functional correlations to disease pathogenesis / Parasitology 142 : 1163 ~ 1170
[학술지(정기간행물)] - Betteridge DJ / 2000 / What is oxidative stress? / Metabolism 49 : 3 ~ 8
[학술지(정기간행물)] - Thannickal VJ / 2000 / Reactive oxygen species in cell signaling / Am J Physiol Lung Cell Mol Physiol 279 : 1005 ~ 1028
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UCI(KEPA) : I410-ECN-0101-2017-513-000776026