지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The objective of this study was to elucidate the effect of Jaeumkanghwatang (JEKHT) on the plasma concentration and pharmacokinetics of tamoxifen in combination therapy as a process of the comprehensive and integrative medicine against breast cancer.
Methods: After 50 mg/kg of tamoxifen treatment, JEKHT 100 mg/kg was orally administered within 5 min. The plasma were collected at 30 min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of JEKHT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (T<SUB>max</SUB>, C<SUB>max</SUB>, AUC, t<SUB>1/2</SUB> and MRT<SUB>inf</SUB>) were analysis as compared with tamoxifen single administered rats.
Results: JEKHT did not influenced on the plasma concentrations and pharmacokinetics of tamoxifen after single oral co-administration, within 5min except for some negligible effects on plasma concentration. The T<SUB>max</SUB>, C<SUB>max</SUB>, AUC, t<SUB>1/2</SUB> and MRT<SUB>inf</SUB> of tamoxifen in co-administered rats were quite similar to those of tamoxifen single treated rats.
Conclusions: Based on the results of the present study, JEKHT did not influenced on the oral bioavailability of tamoxifen, when they were single co-administered within 5min. However, more detail pharmacokinetic studies should be tested to conclude the possibilities that can be used as comprehensive and integrative therapy with JEKHT and tamoxifen for breast cancers, when they were co-administered, like the effects on the pretreatment of JEKHT and after repeat co-administrations.
Methods: After 50 mg/kg of tamoxifen treatment, JEKHT 100 mg/kg was orally administered within 5 min. The plasma were collected at 30 min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of JEKHT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (T<SUB>max</SUB>, C<SUB>max</SUB>, AUC, t<SUB>1/2</SUB> and MRT<SUB>inf</SUB>) were analysis as compared with tamoxifen single administered rats.
Results: JEKHT did not influenced on the plasma concentrations and pharmacokinetics of tamoxifen after single oral co-administration, within 5min except for some negligible effects on plasma concentration. The T<SUB>max</SUB>, C<SUB>max</SUB>, AUC, t<SUB>1/2</SUB> and MRT<SUB>inf</SUB> of tamoxifen in co-administered rats were quite similar to those of tamoxifen single treated rats.
Conclusions: Based on the results of the present study, JEKHT did not influenced on the oral bioavailability of tamoxifen, when they were single co-administered within 5min. However, more detail pharmacokinetic studies should be tested to conclude the possibilities that can be used as comprehensive and integrative therapy with JEKHT and tamoxifen for breast cancers, when they were co-administered, like the effects on the pretreatment of JEKHT and after repeat co-administrations.
목차
Introduction
Materials & methods
Results
Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Layer-by-layer assembled polymeric thin films as prospective drug delivery carriers: design and applications
생체재료학회지
2018 .12
-
Review of COVID-19 Therapeutics by Mechanism: From Discovery to Approval
Journal of Korean Medical Science
2024 .04
-
Expected Next-Generation Drugs
International Neurourology Journal
2017 .06
-
Mechanisms of drug release from advanced drug formulations such as polymeric-based drug-delivery systems and lipid nanoparticles
Journal of Pharmaceutical Investigation
2017 .07
-
Animal Models in Drug Discovery : an Industry Perspective
한국실험동물학회 학술발표대회 논문집
2015 .08
-
HMG CoA-reductase inhibitors를 복용하는 환자의 잠재적 약물상호작용 연구
한국임상약학회지
2020 .01
-
약물군-약물군 조합으로 도출한 약력학적 기전의 추가 병용금기성분
한국임상약학회지
2015 .01
-
Drug Resistance Patterns of Multidrug- and Extensively Drug-Resistant Tuberculosis in Korea: Amplification of Resistance to Oral Second-line Drugs
Annals of Laboratory Medicine
2017 .07
-
의약품 정보 제공 용어의 이해도 평가: 당뇨 및 천식 처방약과 안전상비약을 중심으로
대한보건연구
2016 .01
-
Drug-drug interactions with direct-acting antivirals ? less is more
Clinical and Molecular Hepatology
2021 .01
-
국내 한 상급종합병원의 의약정보실 내 질의응답 사례 분석
병원약사회지
2019 .01
-
Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOCTM) System
Toxicological Research
2015 .06
-
노인 심혈관질환의 다약제 포괄관리
대한의사협회지
2024 .07
-
영·유아와 부모의 약물사용 상관관계에 대한 조사연구
한국임상약학회지
2015 .01
-
간호대학생의 의약품 자가투약 실태, 약물에 대한 지식 및 태도에 관한 연구
의료커뮤니케이션
2018 .01
-
외과계 중환자실의 약물-영양 상호작용과 배합적합성에 대한 처방 현황 및 약물 조정의 영향 평가
병원약사회지
2021 .01
-
고가 및 희귀 의약품의 급여 절차 및 관리
보건의료기술평가
2020 .01
-
The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007
Journal of Korean Medical Science
2017 .01
-
내과계 중환자실 약료 서비스 도입과 약물상호작용 모니터링
한국임상약학회지
2015 .01
-
Drug Repositioning: Exploring New Indications for Existing Drug-Disease Relationships
Endocrinology and Metabolism
2022 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-519-001005760