지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: We evaluated the anti-fatigue effects of Rh2-enriched Korean ginseng (Ginseng Rh2+) using a forced exercise-induced chronic fatigue mouse model.
Methods: ICR male mice were subjected to running wheel for 1 h, 5 days/week during 4 weeks, and running velocity was gradually increased. Each running session was followed by oral administration of distilled water, Ginseng Rh2+ (150 or 300 mg/kg), or N-acetyl-L-cysteine (NAC, 100 mg/kg) 1 h later. The exercise tolerance and forced swimming test were performed to evaluate the fatigue condition.
Results: Chronic forced exercise reduced the physical activity, as evidenced by the behavioral tests, which were notably ameliorated by Ginseng Rh2+ treatment. Ginseng Rh2+ treatment also attenuated the alterations of energy metabolism and oxidative stress in skeletal muscle tissues and/or sera, including malondialdehyde (MDA), lactate concentration and its related factors (lactate dehydrogenase, blood urea nitrogen, and glucose levels).
Conclusion: These findings strongly suggest that Ginseng Rh2+ exerts a potent anti-fatigue effect through modulation of energy metabolism and oxidative response.
Methods: ICR male mice were subjected to running wheel for 1 h, 5 days/week during 4 weeks, and running velocity was gradually increased. Each running session was followed by oral administration of distilled water, Ginseng Rh2+ (150 or 300 mg/kg), or N-acetyl-L-cysteine (NAC, 100 mg/kg) 1 h later. The exercise tolerance and forced swimming test were performed to evaluate the fatigue condition.
Results: Chronic forced exercise reduced the physical activity, as evidenced by the behavioral tests, which were notably ameliorated by Ginseng Rh2+ treatment. Ginseng Rh2+ treatment also attenuated the alterations of energy metabolism and oxidative stress in skeletal muscle tissues and/or sera, including malondialdehyde (MDA), lactate concentration and its related factors (lactate dehydrogenase, blood urea nitrogen, and glucose levels).
Conclusion: These findings strongly suggest that Ginseng Rh2+ exerts a potent anti-fatigue effect through modulation of energy metabolism and oxidative response.
목차
Introduction
Materials and methods
Results
Discussion
References
참고문헌 (32)
참고문헌 신청
[학술지(정기간행물)] - Coon JT / 2002 / Panax ginseng : a systematic review of adverse effects and drug interactions / Drug Saf 25 (5) : 323 ~ 344
[학술지(정기간행물)] - 이상명 / 2015 / Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition / Journal of Ginseng Research 39 (4) : 384 ~ 391
[학술지(정기간행물)] - Kaneko H / 2004 / Proof of the mysterious efficacy of ginseng : basic and clinical trials : clinical effects of medical ginseng, korean red ginseng : specifically, its anti-stress action for prevention of disease / J Pharmacol Sci 95 (2) : 158 ~ 162
[학술지(정기간행물)] - Hong YJ / 2012 / Korean red ginseng(Panax ginseng)ameliorates type 1 diabetes and restores immune cell compartments / J Ethnopharmacol 144 (2) : 225 ~ 233
[학술지(정기간행물)] - 박병진 / 2012 / Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study / Korean Journal of Family Medicine 33 (4) : 190 ~ 196
[학술지(정기간행물)] - 이상명 / 2015 / Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition / Journal of Ginseng Research 39 (4) : 384 ~ 391
[학술지(정기간행물)] - Kaneko H / 2004 / Proof of the mysterious efficacy of ginseng : basic and clinical trials : clinical effects of medical ginseng, korean red ginseng : specifically, its anti-stress action for prevention of disease / J Pharmacol Sci 95 (2) : 158 ~ 162
[학술지(정기간행물)] - Hong YJ / 2012 / Korean red ginseng(Panax ginseng)ameliorates type 1 diabetes and restores immune cell compartments / J Ethnopharmacol 144 (2) : 225 ~ 233
[학술지(정기간행물)] - 박병진 / 2012 / Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study / Korean Journal of Family Medicine 33 (4) : 190 ~ 196
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UCI(KEPA) : I410-ECN-0101-2017-519-001005831