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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.91 No.3
- 발행연도
- 2016.9
- 수록면
- 104 - 111 (8page)
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초록· 키워드
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Purpose: This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma (HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5–10 cm and larger than 10 cm.
Methods: The medical records of 114 patients who underwent hepatectomy for single HCC larger than 5 cm were reviewed and analyzed retrospectively.
Results: In the analysis of the entire cohort of 114 patients, the 5-year overall and diseases-free survival rates were 50% and 29%, respectively. In a comparison of survival rates between groups, tumor sizes of 5 to 10 cm and larger than 10 cm, the overall and disease-free survival rates were not significantly different, respectively (54% vs. 41%, P = 0.433 and 33% vs. 23%, P = 0.083). On multivariate analysis, positive hepatitis B, high prothrombin induced by vitamin K absence or antagonist-II levels over 200 mIU/mL, and vascular invasion (micro- and macrovascular invasion) were independent prognostic factors for recurrence after hepatic resection. However, tumor size larger than 10 cm was not significant for recurrence after resection.
Conclusion: This study shows that surgical resection of solitary HCC larger than 5 cm showed favorable overall survival. And there is no survival difference with tumors between 5–10 cm and larger than 10 cm.
Methods: The medical records of 114 patients who underwent hepatectomy for single HCC larger than 5 cm were reviewed and analyzed retrospectively.
Results: In the analysis of the entire cohort of 114 patients, the 5-year overall and diseases-free survival rates were 50% and 29%, respectively. In a comparison of survival rates between groups, tumor sizes of 5 to 10 cm and larger than 10 cm, the overall and disease-free survival rates were not significantly different, respectively (54% vs. 41%, P = 0.433 and 33% vs. 23%, P = 0.083). On multivariate analysis, positive hepatitis B, high prothrombin induced by vitamin K absence or antagonist-II levels over 200 mIU/mL, and vascular invasion (micro- and macrovascular invasion) were independent prognostic factors for recurrence after hepatic resection. However, tumor size larger than 10 cm was not significant for recurrence after resection.
Conclusion: This study shows that surgical resection of solitary HCC larger than 5 cm showed favorable overall survival. And there is no survival difference with tumors between 5–10 cm and larger than 10 cm.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (18)
참고문헌 신청
[학술지(정기간행물)] - Huang WJ. / 2015 / Tumor size is a major determinant of prognosis of resected stage I hepatocellular carcinoma / Langenbecks Arch Surg 400 : 725 ~ 734
[학술지(정기간행물)] - Vauthey JN. / 2002 / Simplified staging for hepatocellular carcinoma / J Clin Oncol 20 : 1527 ~ 1536
[학술지(정기간행물)] - Chen JH. / 2015 / The safety and adequacy of resection on hepatocellular carcinoma larger than 10 cm : a retrospective study over 10 years / Ann Med Surg(Lond) 4 : 1939 ~
[학술지(정기간행물)] - Kee KM. / 2007 / Validation of clinical AJCC/UICC TNM staging system for hepatocellular carcinoma : analysis of 5, 613 cases from a medical cen ter in southern Taiwan / Int J Cancer 120 : 2650 ~ 2655
[학술지(정기간행물)] - Lee SG. / 2007 / Outcome of patients with huge hepa tocellular carcinoma after primary resec tion and treatment of recurrent lesions / Br J Surg 94 : 320 ~ 326
[학술지(정기간행물)] - Vauthey JN. / 2002 / Simplified staging for hepatocellular carcinoma / J Clin Oncol 20 : 1527 ~ 1536
[학술지(정기간행물)] - Chen JH. / 2015 / The safety and adequacy of resection on hepatocellular carcinoma larger than 10 cm : a retrospective study over 10 years / Ann Med Surg(Lond) 4 : 1939 ~
[학술지(정기간행물)] - Kee KM. / 2007 / Validation of clinical AJCC/UICC TNM staging system for hepatocellular carcinoma : analysis of 5, 613 cases from a medical cen ter in southern Taiwan / Int J Cancer 120 : 2650 ~ 2655
[학술지(정기간행물)] - Lee SG. / 2007 / Outcome of patients with huge hepa tocellular carcinoma after primary resec tion and treatment of recurrent lesions / Br J Surg 94 : 320 ~ 326
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UCI(KEPA) : I410-ECN-0101-2017-514-001094326