지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 126 - 132 (7page)
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초록· 키워드
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Purpose: The aims of this study were to analyze the association between inflammatory cytokine and obstructive sleep apnea (OSA), and to evaluate treatment outcome and changes of plasma inflammatory cytokine levels after oral appliance therapy.
Methods: Twenty-seven subjects who visited Department of Oral Medicine in Seoul National University Dental Hospital were performed nocturnal polysomnography and analyzed plasma C-reactive protein (CRP), interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α levels. Each subject was evaluated with Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). The subjects were classified into 12 OSA patients (apnea-hypopnea index [AHI] ＞5) and 15 control (AHI ≤5) groups. The OSA group was treated with mandibular advancement device (MAD) for 3 months and re-evaluated nocturnal polysomnography and plasma inflammatory cytokine levels.
Results: Plasma TNF-α, IL-10, and IL-6 levels were significantly higher in OSA patients compared to controls. Total AHI showed significant positive correlations with plasma IL-6 and TNF-α levels. Percentage time of SpO₂ ＜90 and lowest SpO₂ were significantly correlated with plasma TNF-α level. ESS showed significant positive correlation with plasma IL-10 level. Total AHI, percentage time of SpO₂ ＜90, lowest SpO₂, and mean SpO₂ were significantly improved after the MAD therapy. Plasma TNF-α level was significantly decreased after MAD therapy.
Conclusions: We suggest that MAD therapy is an effective treatment modality for patients with OSA and can decrease plasma cytokine level.
Methods: Twenty-seven subjects who visited Department of Oral Medicine in Seoul National University Dental Hospital were performed nocturnal polysomnography and analyzed plasma C-reactive protein (CRP), interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α levels. Each subject was evaluated with Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). The subjects were classified into 12 OSA patients (apnea-hypopnea index [AHI] ＞5) and 15 control (AHI ≤5) groups. The OSA group was treated with mandibular advancement device (MAD) for 3 months and re-evaluated nocturnal polysomnography and plasma inflammatory cytokine levels.
Results: Plasma TNF-α, IL-10, and IL-6 levels were significantly higher in OSA patients compared to controls. Total AHI showed significant positive correlations with plasma IL-6 and TNF-α levels. Percentage time of SpO₂ ＜90 and lowest SpO₂ were significantly correlated with plasma TNF-α level. ESS showed significant positive correlation with plasma IL-10 level. Total AHI, percentage time of SpO₂ ＜90, lowest SpO₂, and mean SpO₂ were significantly improved after the MAD therapy. Plasma TNF-α level was significantly decreased after MAD therapy.
Conclusions: We suggest that MAD therapy is an effective treatment modality for patients with OSA and can decrease plasma cytokine level.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
[학술지(정기간행물)] - Kapsimalis F / 2005 / Cytokines and normal sleep / Curr Opin Pulm Med 11 : 481 ~ 484
[단행본] - Krueger MH / 2005 / Principles and practice of sleep medicine / Elsevier
[학술지(정기간행물)] - Krueger JM / 2003 / Humoral links between sleep and the immune system: research issues / Ann N Y Acad Sci 992 : 9 ~ 20
[학술지(정기간행물)] - Opp MR / 2003 / Neural-immune interactions in the regulation of sleep / Front Biosci 8 : d768 ~ d779
[학술지(정기간행물)] - Koskenvuo M / 1985 / Snoring as a risk factor for hypertension and angina pectoris / Lancet 1 : 893 ~ 896
[단행본] - Krueger MH / 2005 / Principles and practice of sleep medicine / Elsevier
[학술지(정기간행물)] - Krueger JM / 2003 / Humoral links between sleep and the immune system: research issues / Ann N Y Acad Sci 992 : 9 ~ 20
[학술지(정기간행물)] - Opp MR / 2003 / Neural-immune interactions in the regulation of sleep / Front Biosci 8 : d768 ~ d779
[학술지(정기간행물)] - Koskenvuo M / 1985 / Snoring as a risk factor for hypertension and angina pectoris / Lancet 1 : 893 ~ 896
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UCI(KEPA) : I410-ECN-0101-2017-515-001418018