지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 64 - 71 (8page)
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Objectives: The objective of this study was to examine the effects of osmotic-controlled release oral delivery system methylphenidate on changes in regional cerebral blood flow (rCBF) in children with attention-deficit hyperactivity disorder (ADHD) using single photon emission computed tomography (SPECT).
Methods: A total of 26 children with ADHD (21 boys, mean age: 9.2±2.05 years old) were recruited. Each ADHD participant was examined for changes in rCBF using technetium-99m-hexamethylpropylene amine oxime brain SPECT before and after 8 weeks methylphenidate medication. Brain SPECT images of pediatric normal controls were selected retrospectively. SPECT images of ADHD children taken before medication were compared with those of pediatric normal controls and those taken after medication using statistical parametric mapping analysis on a voxel-wise basis.
Results: Before methylphenidate medication, significantly decreased rCBF in the cerebellum and increased rCBF in the right precuneus, left anterior cingulate, right postcentral gyrus, right inferior parietal lobule and right precentral gyrus were observed in ADHD children compared to pediatric normal controls (p-value<.0005, uncorrected). After medication, we observed significant hypoperfusion in the left thalamus and left cerebellum compared to pediatric normal controls (p-value<.0005, uncorrected). In the comparison between before medication and after medication, there was significant hyperperfusion in the superior frontal gyrus and middle frontal gyrus and significant hypoperfusion in the right insula, right caudate, right middle frontal gyrus, left subcallosal gyrus, left claustrum, and left superior temporal gyrus after methylphenidate medication (p-value<.0005, uncorrected).
Conclusion: This study supports dysfunctions of fronto-striatal structures and cerebellum in ADHD. We suggest that methylphenidate may have some effects on the frontal lobe, parietal lobe, and cerebellum in children with ADHD.
Methods: A total of 26 children with ADHD (21 boys, mean age: 9.2±2.05 years old) were recruited. Each ADHD participant was examined for changes in rCBF using technetium-99m-hexamethylpropylene amine oxime brain SPECT before and after 8 weeks methylphenidate medication. Brain SPECT images of pediatric normal controls were selected retrospectively. SPECT images of ADHD children taken before medication were compared with those of pediatric normal controls and those taken after medication using statistical parametric mapping analysis on a voxel-wise basis.
Results: Before methylphenidate medication, significantly decreased rCBF in the cerebellum and increased rCBF in the right precuneus, left anterior cingulate, right postcentral gyrus, right inferior parietal lobule and right precentral gyrus were observed in ADHD children compared to pediatric normal controls (p-value<.0005, uncorrected). After medication, we observed significant hypoperfusion in the left thalamus and left cerebellum compared to pediatric normal controls (p-value<.0005, uncorrected). In the comparison between before medication and after medication, there was significant hyperperfusion in the superior frontal gyrus and middle frontal gyrus and significant hypoperfusion in the right insula, right caudate, right middle frontal gyrus, left subcallosal gyrus, left claustrum, and left superior temporal gyrus after methylphenidate medication (p-value<.0005, uncorrected).
Conclusion: This study supports dysfunctions of fronto-striatal structures and cerebellum in ADHD. We suggest that methylphenidate may have some effects on the frontal lobe, parietal lobe, and cerebellum in children with ADHD.
목차
서론
방법
결과
고찰
결론
References
참고문헌 (29)
참고문헌 신청
[단행본] - American Psychiatric Association / 2013 / Diagnostic and statistical manual of mental disorders: DSM-5 / American Psychiatric Publishing
[학술지(정기간행물)] - Greenhill L / 2002 / Guidelines and algorithms for the use of methylphenidate in children with attention-deficit/hyperactivity disorder / J Atten Disord 6 (Suppl 1) : S89 ~ S100
[학술지(정기간행물)] - Engert V / 2008 / Dopaminergic and noradrenergic contributions to functionality in ADHD: the role of methylphenidate / Curr Neuropharmacol 6 : 322 ~ 328
[학술지(정기간행물)] - Bush G / 2005 / Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions / Biol Psychiatry 57 : 1273 ~ 1284
[학술지(정기간행물)] - Seidman LJ / 2005 / Structural brain imaging of attention-deficit/hyperactivity disorder / Biol Psychiatry 57 : 1263 ~ 1272
[학술지(정기간행물)] - Greenhill L / 2002 / Guidelines and algorithms for the use of methylphenidate in children with attention-deficit/hyperactivity disorder / J Atten Disord 6 (Suppl 1) : S89 ~ S100
[학술지(정기간행물)] - Engert V / 2008 / Dopaminergic and noradrenergic contributions to functionality in ADHD: the role of methylphenidate / Curr Neuropharmacol 6 : 322 ~ 328
[학술지(정기간행물)] - Bush G / 2005 / Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions / Biol Psychiatry 57 : 1273 ~ 1284
[학술지(정기간행물)] - Seidman LJ / 2005 / Structural brain imaging of attention-deficit/hyperactivity disorder / Biol Psychiatry 57 : 1263 ~ 1272
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UCI(KEPA) : I410-ECN-0101-2017-516-001610308