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논문 기본 정보

자료유형
학술저널
저자정보
김욱 (Korea Institute of Radiological and Medical Sciences) 우상근 (Korea Institute of Radiological and Medical Sciences) 강주현 (Korea Institute of Radiological and Medical Sciences) 임상무 (Korea Institute of Radiological and Medical Sciences)
저널정보
한국컴퓨터정보학회 한국컴퓨터정보학회논문지 한국컴퓨터정보학회 논문지 제21권 제12호(통권 제153호)
발행연도
2016.12
수록면
11 - 18 (8page)

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초록· 키워드

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Magnetic resonance image (MRI) is widely used in brain research field and medical image. Especially, non-invasive brain activation acquired image technique, which is functional magnetic resonance image (fMRI) is used in brain study. In this study, we investigate brain activation occurred by LED light stimulation. For investigate of brain activation in experimental small animal, we used high magnetic field 9.4T MRI. Experimental small animal is Balb/c mouse, method of fMRI is using echo planar image (EPI). EPI method spend more less time than any other MRI method. For this reason, however, EPI data has low contrast. Due to the low contrast, image pre-processing is very hard and inaccuracy. In this study, we planned the study protocol, which is called block design in fMRI research field . The block designed has 8 LED light stimulation session and 8 rest session. All block is consist of 6 EPI images and acquired 1 slice of EPI image is 16 second. During the light session, we occurred LED light stimulation for 1 minutes 36 seconds. During the rest session, we do not occurred light stimulation and remain the light off state for 1 minutes 36 seconds. This session repeat the all over the EPI scan time, so the total spend time of EPI scan has almost 26 minutes. After acquired EPI data, we performed the analysis of this image data. In this study, we analysis of EPI data using statistical parametric map (SPM) software and performed image pre-processing such as realignment, co-registration, normalization, smoothing of EPI data. The pre-processing of fMRI data have to segmented using this software. However this method has 3 different method which is Gaussian nonparametric, warped modulate, and tissue probability map. In this study we performed the this 3 different method and compared how they can change the result of fMRI analysis results. The result of this study show that LED light stimulation was activate superior colliculus region in mouse brain. And the most higher activated value of segmentation method was using tissue probability map. this study may help to improve brain activation study using EPI and SPM analysis.

목차

Abstract
Ⅰ. Introduction
Ⅱ. Materials and Methods
Ⅲ. Result
Ⅳ. Conclusions
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UCI(KEPA) : I410-ECN-0101-2017-004-001969723