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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 211 - 214 (4page)
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초록· 키워드
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House dust mite is an essential allergen in the pathogenesis of allergic diseases. Abnormal regulation of neutrophil apoptosis is an important pathogenic process in allergic diseases. In the present study, we investigated the effects of house dust mites on spontaneous apoptosis of neutrophils and its associated mechanisms. Extract of Dermatophagoides pteronissinus (DP) inhibited neutrophil apoptosis in a time-dependent manner. Cycloheximide (CHX), an inhibitor of translation, increased apoptosis of DP-treated neutrophils as well as control cells. The pro-apoptotic effect of CHX was blocked by DP in neutrophils. In addition, DP increased the phosphorylation of Bad in a time-dependent manner, indicating that it exerted an inhibitory effect on the function of Bad. These results suggest that DP has anti-apoptotic effects of neutrophils and may regulate protein synthesis and activation of Bad. Moreover, these findings may shed light on elucidation of allergy pathogenesis due to house dust mites.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (15)
참고문헌 신청
[학술지(정기간행물)] - Bascom R / 1988 / The influx of inflammatory cells into nasal washings during the late response to antigen challenge: effect of steroid pretreatment / Am Rev Respir Dis 138 : 406 ~ 412
[학술지(정기간행물)] - Bergmann A. / 2002 / Survival signaling goes BAD / Developmental Cell 3 : 607 ~ 608
[학술지(정기간행물)] - 강보경 / 2014 / The House dust Mite Allergen, Dermatophagoides pteronyssinus Regulates the Constitutive Apoptosis and Cytokine Secretion of Human Eosinophils / 대한의생명과학회지 20 (1) : 39 ~ 42
[학술지(정기간행물)] - Kim DH / 2015 / House dust mite allergen regulates constitutive apoptosis of normal and asthmatic neutrophils via Toll-like receptor 4 / PLoS One 11 : 3995 ~ 4001
[학술지(정기간행물)] - 김인식 / 2013 / Effect of House Dust Mite and CCL2 on S100A8 and S100A9 Expression in Human Monocytes / 대한의생명과학회지 19 (4) : 344 ~ 347
[학술지(정기간행물)] - Bergmann A. / 2002 / Survival signaling goes BAD / Developmental Cell 3 : 607 ~ 608
[학술지(정기간행물)] - 강보경 / 2014 / The House dust Mite Allergen, Dermatophagoides pteronyssinus Regulates the Constitutive Apoptosis and Cytokine Secretion of Human Eosinophils / 대한의생명과학회지 20 (1) : 39 ~ 42
[학술지(정기간행물)] - Kim DH / 2015 / House dust mite allergen regulates constitutive apoptosis of normal and asthmatic neutrophils via Toll-like receptor 4 / PLoS One 11 : 3995 ~ 4001
[학술지(정기간행물)] - 김인식 / 2013 / Effect of House Dust Mite and CCL2 on S100A8 and S100A9 Expression in Human Monocytes / 대한의생명과학회지 19 (4) : 344 ~ 347
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UCI(KEPA) : I410-ECN-0101-2017-510-002026433