지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.31
- 발행연도
- 2016.12
- 수록면
- 74 - 77 (4page)
이용수
초록· 키워드
오류제보하기
An analysis of patients and fatalities due to exposure to polyhexamethylene guanidine (PHMG) shows that PHMG causes mainly lung diseases such as pulmonary fibrosis. However, no research on the other organs has been conducted on this matter yet. So, an in-depth discussion on toxicological techniques is needed to determine whether or not PHMG is toxic to organs other than just the lungs. For the test of target organ toxicity by PHMG exposure, a toxicokinetic study must first be conducted. However, measurement method for PHMG injected into the body has not yet been established because it is not easy to analyze polymer PHMG, so related base studies on analytical technique for PHMG including radio-labeling chemistry must come first. Moreover, research on exposure-biomarker and effect-biomarker must also be conducted, primarily related to clinical application. Several limitations seem to be expected to apply the biomarker study to the patient because much time has passed after exposure to the humidifier disinfectant. It is why a more comprehensive toxicological researches must be introduced to the causality for the victims.
목차
Introduction
Toxicity and Target Distribution ofPolyhexamethylene Guanidine Based on the Exposure Routes
Toxicological Methods That Could Be Applied to the Criteria for Victims of the Humidifier Disinfectant Case
Relief Plan for Victims of the Humidifier Disinfectant Case and the Basis for the Decision
Conclusion
References
참고문헌 (8)
참고문헌 신청
Asian Citizen’s Center for Environment and Health / Population survey of humidifier disinfectant use
최예용 / 2016 / Humidifier disinfectants, unfinished stories / 환경독성보건학회지 31:1~2
Ostapenko YN / 2011 / Acute cholestatic liver injury caused by polyhexamethyleneguanidine hydrochloride admixed to ethyl alcohol / Clin Toxicol (Phila) 49(6):471~477
Asiedu-Gyekye IJ / 2014 / A preliminary safety evaluation of polyhexamethylene guanidine hydrochloride / Int J Toxicol 33(6):523~531
Kim HR / 2016 / Polyhexamethylene guanidine phosphate aerosol particles induce pulmonary inflammatory and fibrotic responses / Arch Toxicol 90(3):617~632
최예용 / 2016 / Humidifier disinfectants, unfinished stories / 환경독성보건학회지 31:1~2
Ostapenko YN / 2011 / Acute cholestatic liver injury caused by polyhexamethyleneguanidine hydrochloride admixed to ethyl alcohol / Clin Toxicol (Phila) 49(6):471~477
Asiedu-Gyekye IJ / 2014 / A preliminary safety evaluation of polyhexamethylene guanidine hydrochloride / Int J Toxicol 33(6):523~531
Kim HR / 2016 / Polyhexamethylene guanidine phosphate aerosol particles induce pulmonary inflammatory and fibrotic responses / Arch Toxicol 90(3):617~632
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UCI(KEPA) : I410-ECN-0101-2017-539-002198379