Intra-individual variability of mycophenolic acid concentration according to renal function in liver transplant recipients receiving mycophenolate monotherapy

Shin Hwang; Gi-Won Song; Dong-Hwan Jung; Gil-Chun Park; Chul-Soo Ahn; Deok-Bog Moon; Tae-Yong Ha; Ki-Hun Kim; Sung-Gyu Lee

추천

검색

질문

자료유형: 학술저널

저자정보: Shin Hwang (University of Ulsan College of Medicine) Gi-Won Song (University of Ulsan College of Medicine) Dong-Hwan Jung (University of Ulsan College of Medicine) Gil-Chun Park (University of Ulsan College of Medicine) Chul-Soo Ahn (University of Ulsan College of Medicine) Deok-Bog Moon (University of Ulsan College of Medicine) Tae-Yong Ha (University of Ulsan College of Medicine) Ki-Hun Kim (University of Ulsan College of Medicine) Sung-Gyu Lee (University of Ulsan College of Medicine)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제21권 제1호

발행연도: 2017.2

수록면: 11 - 16 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Backgrounds/Aims: Mycophenolate mofetil (MMF) has wide inter- and intra-individual variability of mycophenolic acid (MPA) after liver transplantation (LT). On this study, we aimed to analyse the intra-individual variability of MPA concentration in stable adult LT recipients receiving MMF monotherapy and develop a method to determine the target level in the situation of wide intra-individual variability. Methods: This retrospective cross-sectional study included 30 LT recipients. All patients received MMF monotherapy at a dose of 500 mg twice daily for ≥2 years and were divided into two groups based on renal function. MPA concentration-associated values were presented as mean with standard deviation and coefficient of variation (CV). Results: The normal renal function group (n=15) showed a mean 12-hour MPA concentration of 2.5±0.5 ㎍/ml (range, 1.8±0.5 to 3.6±0.7 ㎍/ml) and a mean CV of 20.4±7.7% (range, 8.7% to 39.4%). In the renal dysfunction group (n=15), the 12-hour MPA concentration fluctuated more widely with a mean value of 3.7±0.9 ㎍/ml (range, 2.8±0.8 to 5.1±1.2 ㎍/ml) and a mean CV of 24.5±4.9% (range, 17.1% to 37.5%). The 12-hour MPA concentration was significantly higher in the renal dysfunction group, as compared to the normal renal function group (p=0.001); whereas, the CV was not significantly different between the two groups (p=0.093). Conclusions: We determined the inter- and intra-individual variability of 12-hour MPA concentration after LT. The results suggested that therapeutic drug monitoring of MPA is necessary due to the inter-individual and intra-individual variability of MMF pharmacokinetics, especially in LT recipients with renal dysfunction.

#Renal function #Mycophenolate mofetil #Mycophenolic acid #Variability #Liver transplantation

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!