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Inhibitory effect of Petalonia binghamiae on neuroinflammation in LPS-stimulated microglial cells
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LPS에 의해 활성화된 미세아교세포에서 미역쇠 추출물의 신경염증 보호 효과

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Type
Academic journal
Author
Park, Jae Hyeon (제주대학교) Kim, Sung Hun (제주대학교) Lee, Sun Ryung (제주대학교)
Journal
The Korean Nutrition Society Journal of Nutrition and Health Vol.50 No.1 KCI Accredited Journals SCOPUS
Published
2017.2
Pages
25 - 31 (7page)

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Inhibitory effect of Petalonia binghamiae on neuroinflammation in LPS-stimulated microglial cells
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Purpose: Neuroinflammation is mediated by activation of microglia implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer"s disease and Parkinson"s disease. Inhibition of neuroinflammation may be an effective solution to treat these brain disorders. Petalonia binghamiae is known as a traditional food, based on multiple biological activities such as anti-oxidant and anti-obesity. In present study, the anti-neuroinflammatory potential of Petalonia binghamiae was investigated in LPS-stimulated BV2 microglial cells. Methods: Cell viability was measured by MTT assay. Production of nitric oxide (NO) was examined using Griess reagent. Expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) was detected by Western blot analysis. Activation of nuclear factor κB (NF-κB) signaling was examined by nuclear translocation of NF-κB p65 subunit and phosphorylation of IκB. Results: Extract of Petalonia binghamiae significantly inhibited LPS-stimulated NO production and iNOS/COX-2 protein expression in a dose-dependent manner without cytotoxicity. Pretreatment with Petalonia binghamiae suppressed LPS-induced NF-κB p65 nuclear translocation and phosphorylation of IκB. Co-treatment with Petalonia binghamiae and pyrrolidine duthiocarbamate (PDTC), an NF-κB inhibitor, reduced LPS-stimulated NO release compared to that in PB-treated or PDTC-treated cells. Conclusion: The present results indicate that extract of Petalonia binghamiae exerts anti-neuroinflammation activities, partly through inhibition of NF-κB signaling. These findings suggest that Petalonia binghamiae might have therapeutic potential in relation to neuroinflammation and neurodegenerative diseases.
#Petalonia binghamiae #neuroinflammation #microglia #nitric oxide #nuclear factor-κB

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Nakagawa Y, Chiba K. Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases. Pharmaceuticals (Basel) 2014; 7(12): 1028-1048. Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 2010; 87(5): 779-789. Griffin WS. Inflammation and neurodegenerative diseases. Am J Clin Nutr 2006; 83(2): 470S-474S. Chung YC, Ko HW, Bok E, Park ES, Huh SH, Nam JH, Jin BK. The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB Rep 2010; 43(4): 225-232. Gonzalez H, Elgueta D, Montoya A, Pacheco R. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases. J Neuroimmunol 2014; 274(1-2): 1-13.

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UCI(KEPA) : I410-ECN-0101-2017-594-002243458