Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats

Gökhan Karaca; Oktay Aydin; Faruk Pehlivanli; Canan Altunkaya; Hafize Uzun; Osman Güler

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자료유형: 학술저널

저자정보: Gökhan Karaca (Kırıkkale University) Oktay Aydin (Kırıkkale University) Faruk Pehlivanli (Kırıkkale University) Canan Altunkaya (Kırıkkale University) Hafize Uzun (Istanbul University) Osman Güler (Kırıkkale University)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.92 No.6

발행연도: 2017.6

수록면: 396 - 401 (6page)

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Purpose: The effectiveness of platelet-rich plasma (PRP), thymoquinone, and zeolite in corrosive esophageal burns was investigated in a rat model.
Methods: Four groups were comprised as containing 10 rats in each group. For group I, oesophagitis was induced and no other procedure was performed (control group). For group II, oesophagitis was induced and thymoquinone was administered for 1 week via oral gavage once a day (thymoquinone group). For group III, oesophagitis was induced for 1 week via oral gavage once a day (PRP group). For group IV, oesophagitis was induced and zeolite was administered for 1 week via oral gavage once a day (zeolite group). On the 10th day, the rats were sacrificed under anaesthesia and venous blood sampling was performed from the vena portae. The oesophaguses were totally excised. Biochemically, interleukin (IL)-1B, IL-6, TNF-α, and MCP-1 were examined from venous blood. Inflammation score was evaluated histopathologically in oesophageal tissue that was collected.
Results: There was a statistically significant difference among groups in terms of IL-1, IL-6, MCP levels, compared to the control group; median IL-1, IL-6, MCP levels of thymoquinone, PRP, and zeolite groups were statistically significantly lower. There was a statistically significant difference among groups in terms of inflammation scores, compared to group I; median inflammation scores of groups II, III and IV were statistically significantly lower thymoquinone.
Conclusion: PRP, and zeolite exhibited positive effect on recovery in oesophagitis by reducing inflammation in the involved segment.

#Thymoquinone #Platelet-rich plasma #Zeolite #Oesophagitis #Inflammation

참고문헌 (30)

참고문헌 신청

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[학술지(정기간행물)] - Haller JA Jr / 1971 / Pathophysiology and management of acute corrosive burns of the esophagus : results of treatment in 285children / J Pediatr Surg 6 : 578 ~ 584

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[학술지(정기간행물)] - Contardo C. / 1998 / Ingestion of corrosive substances / Rev Gastroenterol Peru 18 : 264 ~ 272

[학술지(정기간행물)] - Cardona JC / 1957 / Corrosive esophagitis / Am J Surg 93 : 242 ~ 247

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