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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.22 No.2
- 발행연도
- 2017.6
- 수록면
- 118 - 123 (6page)
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This study was conducted to investigate the anti-adipogenic activity of esculetin (ECT) which is reported to be attributable to the modulation of antioxidant enzymes during adipogenesis. After six days of ECT treatment of 3T3-L1 cells, lipid accumulation was determined by Oil red O staining. The levels of glutathione (GSH) and reactive oxygen species (ROS), and the activities of antioxidant enzymes including glutathione reductase, glutathione peroxidase (GPx), and catalase were examined. In addition, the protein expression of glutamate-cysteine ligase catalytic subunit (GCLC) and heme oxygenase-1 (HO-1) was measured by Western blot. ECT significantly inhibited lipid accumulation by approximately 80% and ROS production in a concentration-dependent manner. GSH level and GPx activity were increased by ECT by approximately 1.3-fold and 1.7-fold compared to the control group, respectively. GCLC and HO-1 expression were elevated by ECT. These results showed that ECT treatments strongly inhibit adipogenesis, increase GSH level, and upregulate the expression of GCLC and HO-1, possibly by decreasing ROS production in 3T3-L1 cells during adipogenesis.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (37)
참고문헌 신청
[학술지(정기간행물)] - Shah AM / 2004 / Free radicals and redox signalling in cardiovascular disease / Heart 90 : 486 ~ 487
[학술지(정기간행물)] - Halliwell B / 1992 / Free radicals, antioxidants, and human disease : where are we now? / J Lab Clin Med 119 : 598 ~ 620
[학술지(정기간행물)] - Furukawa S / 2004 / Increased oxidative stress in obesity and its impact on metabolic syndrome / J Clin Invest 114 : 1752 ~ 1761
[학술지(정기간행물)] - Lee H / 2009 / Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion / J Biol Chem 284 : 10601 ~ 10609
[학술지(정기간행물)] - Messarah M / 2007 / The impact of thyroid activity variations on some oxidizing-stress parameters in rats / C R Biol 330 : 107 ~ 112
[학술지(정기간행물)] - Halliwell B / 1992 / Free radicals, antioxidants, and human disease : where are we now? / J Lab Clin Med 119 : 598 ~ 620
[학술지(정기간행물)] - Furukawa S / 2004 / Increased oxidative stress in obesity and its impact on metabolic syndrome / J Clin Invest 114 : 1752 ~ 1761
[학술지(정기간행물)] - Lee H / 2009 / Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion / J Biol Chem 284 : 10601 ~ 10609
[학술지(정기간행물)] - Messarah M / 2007 / The impact of thyroid activity variations on some oxidizing-stress parameters in rats / C R Biol 330 : 107 ~ 112
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