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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 75 - 86 (12page)
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초록· 키워드
오류제보하기
Human physiology and pathology can be affected by different nutritional conditions. At cellular level, the availability of a nutritional component not only mediates metabolic reactions but also transmits signals for diverse biological activities. Epigenetic regulation such as DNA methylation and histone post-translational modifications is considered as one of the nutrient-mediated signaling receivers as almost all of the epigenetic enzyme activities require intermediary metabolites as cofactors. The gut microbiome as "forgotten organ" has been suggested as a metabolite generator as well as a nutrient sensor for its host organism, affecting human health and diseases. Given the metabolite-dependent activities of epigenetic regulators, the gut microbiome has a high potential to influence the epigenetics in human physiology. Here, I review the involvement of gut microbiome in diverse human diseases and the mechanisms of epigenetic regulation by different metabolites. Thereafter, I discuss how the gut microbiome-generated metabolites affect host epigenetics, raising a possibility to develop a therapeutic intervention based on the interaction between the microbiome and epigenetics for human health.
목차
INTRODUCTION
Gut Microbiome and Human Diseases
Mechanisms of Epigenetic Regulation
Influence of Metabolic Alterations on Epigenetics
Effect of the Gut Microbiome-generated Metabolites on Epigenetics
CONCLUSION
REFERENCES
참고문헌 (65)
참고문헌 신청
[학술지(정기간행물)] - O'Hara AM / 2006 / The gut flora as a forgotten organ / EMBO Rep 7 : 688 ~ 693
[학술지(정기간행물)] - Bianconi E / 2013 / An estimation of the number of cells in the human body / Ann Hum Biol 40 : 463 ~ 471
[학술지(정기간행물)] - Devaraj S / 2013 / The human gut microbiome and body metabolism: implications for obesity and diabetes / Clin Chem 59 : 617 ~ 628
[학술지(정기간행물)] - Human Microbiome Project Consortium / 2012 / Structure, function and diversity of the healthy human microbiome / Nature 486 : 207 ~ 214
[학술지(정기간행물)] - Cho I / 2012 / The human microbiome: at the interface of health and disease / Nat Rev Genet 13 : 260 ~ 270
[학술지(정기간행물)] - Bianconi E / 2013 / An estimation of the number of cells in the human body / Ann Hum Biol 40 : 463 ~ 471
[학술지(정기간행물)] - Devaraj S / 2013 / The human gut microbiome and body metabolism: implications for obesity and diabetes / Clin Chem 59 : 617 ~ 628
[학술지(정기간행물)] - Human Microbiome Project Consortium / 2012 / Structure, function and diversity of the healthy human microbiome / Nature 486 : 207 ~ 214
[학술지(정기간행물)] - Cho I / 2012 / The human microbiome: at the interface of health and disease / Nat Rev Genet 13 : 260 ~ 270
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UCI(KEPA) : I410-ECN-0101-2018-475-000980598