지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: We investigated the effect of acupuncture on memory function in relation with neurogenesis in old rats.
Methods: In this study, a step-down avoidance task for short-term memory and Y-maze task for spatial memory capability were conducted. Western blot analysis for brain-derived neurotorphic factor (BDNF) and tyrosine kinase B (TrkB), and immunohistochemistry for 5-bromo-2’-deoxyuridine (BrdU) were performed.
Results: Short-term memory and spatial memories were decreased in the old-aged rats. Expressions of BDNF and TrkB in the hippocampus were significantly decreased in the old-aged rats. Neurogenesis in the hippocampal dentate gyrus was also decreased in the old-aged rats. However, acupuncture treatment alleviated impairment of short-term and spatial memories induced by ageing. Acupuncture also increased the expressions of BDNF and TrkB and enhanced neurogenesis in the hippocampus. The present study showed that acupuncture alleviated ageing-induced short-term and spatial memory loss by increasing of BDNF and neurogenesis. Acupuncture at ST41-acupoint showed most potent effect than at ST36-acupoint or non-acupoint.
Conclusions: Acupuncture might be used as the effective therapeutic modality to ameliorate the age-related decrease of brain functions.
Methods: In this study, a step-down avoidance task for short-term memory and Y-maze task for spatial memory capability were conducted. Western blot analysis for brain-derived neurotorphic factor (BDNF) and tyrosine kinase B (TrkB), and immunohistochemistry for 5-bromo-2’-deoxyuridine (BrdU) were performed.
Results: Short-term memory and spatial memories were decreased in the old-aged rats. Expressions of BDNF and TrkB in the hippocampus were significantly decreased in the old-aged rats. Neurogenesis in the hippocampal dentate gyrus was also decreased in the old-aged rats. However, acupuncture treatment alleviated impairment of short-term and spatial memories induced by ageing. Acupuncture also increased the expressions of BDNF and TrkB and enhanced neurogenesis in the hippocampus. The present study showed that acupuncture alleviated ageing-induced short-term and spatial memory loss by increasing of BDNF and neurogenesis. Acupuncture at ST41-acupoint showed most potent effect than at ST36-acupoint or non-acupoint.
Conclusions: Acupuncture might be used as the effective therapeutic modality to ameliorate the age-related decrease of brain functions.
목차
Introduction
Materials and methods
Results
Discussion
References
참고문헌 (32)
참고문헌 신청
Colombo PJ, Gallagher M. Individual differences in spatial memory and striatal ChAT activity among young and aged rats. Neurobiol Learn Mem. 1998;70:314-327.
Nyffeler M, Yee BK, Feldon J, Knuesel I. Abnormal differentiation of newborn granule cells in age-related working memory impairments. Neurobiol Aging. 2010;31:1956-1974.
Mattson MP, Magnus T. Ageing and neuronal vulnerability. Nat Rev Neurosci. 2006;7:278-294.
Gould E, Tanapat P, Hastings NB, Shors TJ. Neurogenesis in adulthood: a possible role in learning. Trends Cogn Sci. 1999;3:186-192.
Leuner B, Kozorovitskiy Y, Gross CG, Gould E. Diminished adult neurogenesis in the marmoset brain precedes old age. Proc Natl Acad Sci USA. 2007;23:17169-17173.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Exploring Acupuncture Actions in the Body and Brain
Journal of Acupuncture & Meridian Studies
2022 .06
-
Comparison between the Effectiveness of Manual Acupuncture and Laser Acupuncture at EX-B3 Weiwanxiashu in a Rat Model of Type 2 Diabetes
Journal of Acupuncture & Meridian Studies
2021 .01
-
군진의학에서의 침치료 활용을 위한 연구동향 고찰
한방재활의학과학회지
2016 .01
-
폐경 후 고혈압 전단계 및 1기 고혈압에 대한 침 치료 효과: 무작위 대조 예비연구
Korean Journal of Acupuncture
2017 .01
-
Effect of acupuncture on short-term memory and apoptosis after transient cerebral ischemia in gerbils
대한한의학회지
2018 .12
-
The History of Liquid Ear Acupuncture and the Current Scientific State of the Art
Journal of Pharmacopuncture
2016 .01
-
Effect of Manual Acupuncture Stimulation at “Bai-Hui” (GV 20) or “Yinta´ng” (Ex-HN3) on Depressed Rats
Journal of Acupuncture & Meridian Studies
2017 .01
-
Comments on Acupuncture in Post-Stroke Shoulder Pain Syndrome with Multiple Sclerosis: A Case Study
Journal of Acupuncture & Meridian Studies
2021 .10
-
비특이적 목 통증에 사용된 침구치료에 대한 체계적 문헌고찰
Korean Journal of Acupuncture
2017 .01
-
대한경락경혈학회지 연구동향
Korean Journal of Acupuncture
2016 .01
-
Pubmed로 검색한 소아 천식의 침술 및 혈위약물요법 치료에 관한 문헌고찰
대한한방소아과학회지
2015 .01
-
건강인군과 편마비군에 시행한 침, 전침 및 박동성 전기자장 치료가 상지의 체열 변화에 미치는 영향
한방재활의학과학회지
2016 .01
-
A Review of Acupuncture Treatment for Primary Headache Disorders in Korea
대한침구의학회지
2019 .01
-
Sham Acupuncture Is Not Just a Placebo
Journal of Acupuncture & Meridian Studies
2022 .12
-
A New Theory for Acupuncture: Promoting Robust Regulation
Journal of Acupuncture & Meridian Studies
2018 .01
-
카드뮴으로 유발된 산화적 스트레스에 대한 침 자극의 신장 보호 효과
대한침구의학회지
2015 .01
-
Treadmill Exercise Alleviates Circadian Rhythm Disruption- Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
International Neurourology Journal
2019 .01
-
자폐스펙트럼장애의 침치료에 대한 최근 임상 연구 동향- RCT 중심으로 -
대한한방소아과학회지
2015 .01
-
체질침법 연구 경향을 통한 사상체질침법 정립에 관한 연구
JSCM : Journal of Sasang constitutional medicine
2019 .01
-
알레르기 비염의 침 치료에 대한 체계적 고찰
대한한방내과학회지
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-519-000986271