지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 305 - 313 (9page)
이용수
초록· 키워드
오류제보하기
Accumulating epidemiological evidence indicates that exposure to fine air pollution particles (APPs) is associated with a variety of adverse health effects. However, the exact physiochemical properties and biological toxicities of fine APPs are still not well characterized. We collected four types of fine particle (FP) (diesel exhaust particles [DEPs], natural organic combustion [NOC] ash, synthetic organic combustion [SOC] ash, and yellow sand dust [YSD]) and investigated their physicochemical properties and in vitro biological toxicity. DEPs were almost entirely composed of ultrafine particles (UFPs), while the NOC, SOC, and YSD particles were a mixture of UFPs and FPs. The main elements in the DEPs, NOC ash, SOC ash, and YSD were black carbon, silicon, black carbon, and silicon, respectively. DEPs exhibited dose-dependent mutagenicity even at a low dose in Salmonella typhimurium TA 98 and 100 strains in an Ames test for genotoxicity. However, NOC, SOC, and YSD particles did not show any mutagenicity at high doses. The neutral red uptake assay to test cell viability revealed that DEPs showed dose-dependent potent cytotoxicity even at a low concentration. The toxicity of DEPs was relatively higher than that of NOC, SOC, and YSD particles. Therefore, these results indicate that among the four FPs, DEPs showed the highest in vitro biological toxicity. Additional comprehensive research studies such as chemical analysis and in vivo acute and chronic inhalation toxicity tests are necessary to determine and clarify the effects of this air contaminant on human health.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
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Sancini, G / 2014 / Health risk assessment for air pollutants: alterations in lung and cardiac gene expression in mice exposed to Milano winter fine particulate matter (PM 2.5) / PLoS ONE 9:e109685
Jassal, M.S / 2015 / Pediatric asthma and ambient pollutant levels in industrializing nations / Int. Health 7:7~15
Adams, K / 2015 / Particulate matter components, sources, and health: Systematic approaches to testing effects / J. Air Waste Manag. Assoc 65:544~558
Luanpitpong, S / 2014 / Appalachian mountaintop mining particulate matter induces neoplastic transformation of human bronchial epithelial cells and promotes tumor formation / Environ. Sci. Technol 48:12912~12919
Sancini, G / 2014 / Health risk assessment for air pollutants: alterations in lung and cardiac gene expression in mice exposed to Milano winter fine particulate matter (PM 2.5) / PLoS ONE 9:e109685
Jassal, M.S / 2015 / Pediatric asthma and ambient pollutant levels in industrializing nations / Int. Health 7:7~15
Adams, K / 2015 / Particulate matter components, sources, and health: Systematic approaches to testing effects / J. Air Waste Manag. Assoc 65:544~558
Luanpitpong, S / 2014 / Appalachian mountaintop mining particulate matter induces neoplastic transformation of human bronchial epithelial cells and promotes tumor formation / Environ. Sci. Technol 48:12912~12919
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UCI(KEPA) : I410-ECN-0101-2018-513-001357743