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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.32
- 발행연도
- 2017.12
- 수록면
- 15 - 20 (6page)
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초록· 키워드
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Zinc pyrithione (ZP) is commonly used to prevent dandruff and seborrheic dermatitis. Many consumers are exposed daily to high doses of ZP, causing serious concerns about its toxicity. The reproductive and developmental toxicities were previously reported in pregnant rats. However, the estrogenic activity of ZP at varying degrees of exposure has been rarely studied. Thus, we performed an uterotrophic assay, E-screen assay, and gene expression profiling to assess the estrogenic activity of ZP. For the uterotrophic assay, ZP (2, 10, or 50 mg/kg/d) was subcutaneously administered to ovariectomized rats every day for three days. Uteri were extracted 24 hours after the last dose. Then, wet and blotted uterine weights were measured. For the E-screen essay, MCF-7 cells (a breast cancer cell line) were exposed to 10<SUP>-9</SUP> to 10<SUP>-6</SUP> M of ZP, and cell proliferation was then measured. For the gene expression analysis, changes of gene expression levels in uterine samples taken for the uterotrophic assay were analyzed. In the uterotrophic assay, the concentration of ZP had no significant effect on uterine weight. In the E-screen assay, ZP at any concentration showed no significant increase in MCF-7 cell proliferation, compared to the control group. However, 10<SUP>-6</SUP> M of ZP significantly reduced cell viability. The changes in gene expression slightly differed between the ZP and control groups. The in vivo and in vitro assays, together with gene expression analysis, demonstrated that ZP showed no significant estrogenic activity.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
Gupta M, Mahajan VK, Mehta KS, Chauhan PS. Zinc therapy in dermatology: a review. Dermatol Res Pract 2014;2014:709152.
Bibi Nitzan Y, Cohen AD. Zinc in skin pathology and care. Zinc in skin pathology and care. J Dermatolog Treat 2006;17(4):205-210.
Scientific Committee on Consumer Safety. Opinion on zinc pyrithione: COLIPA n° P81; 2013 [cited 2017 Feb 15]. Available from: file:///C:/Users/user/Downloads/NDAQ13004ENN_002.pdf.
Gupte TE, Gaikwad UV, Naik SR. Experimental studies (in vitro) on polyene macrolide antibiotics with special reference to hamycin against Malassezia ovale. Comp Immunol Microbiol Infect Dis 1999;22(2):93-102.
Warner RR, Schwartz JR, Boissy Y, Dawson TL Jr. Dandruff has an altered stratum corneum ultrastructure that is improved with zinc pyrithione shampoo. J Am Acad Dermatol 2001;45(6):897-903.
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UCI(KEPA) : I410-ECN-0101-2018-539-001597034