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논문 기본 정보

자료유형
학술저널
저자정보
Jae Gwang Park (Sungkyunkwan University) Wie-Soo Kang (Korea Bird Wild Ginseng) Kyung Tae Park (Kangwon National University) Dong Jun Park (Kangwon National University) Adithan Aravinthan (Chonbuk National University) Jong-Hoon Kim (Chonbuk National University) Jae Youl Cho (Sungkyunkwan University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.40 No.3
발행연도
2016.7
수록면
304 - 308 (5page)

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초록· 키워드

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Background: Joboksansam, Korean bird wild ginseng, is an artificially cultivated wild ginseng germinated from bird feces. Although numerous pharmacologic activities of wild ginsengs have been reported, the beneficial effect of joboksansam in cancer has not been elucidated. In this study, we investigated the in vivo and in vitro anticancer activities of joboksansam powder.
Methods: To evaluate the in vivo anticancer activity of joboksansam, we established a xenograft mouse model bearing RMA cell-derived cancer. Direct cytotoxicity induced by joboksansam powder was also investigated in vitro using (3-4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay. The inhibitory activity of this powder on the activation of cell survival signaling involving Akt and Src was examined with immunoblot analysis.
Results: Joboksansam powder displayed strong inhibitory activity against the increased tumor size, increased weight of total body and cancer tissues, and mortality of tumor-bearing mice. Joboksansam powder also suppressed the activation of survival regulatory enzymes Akt and Src, as assessed by phosphorylation levels in the immunoblot analysis of tumor tissues. Interestingly, the viability of RMA cells in vitro was directly decreased by joboksansam treatment.
Conclusion: Overall, our results strongly suggest that joboksansam powder has the potential to protect against cancer generation by direct cytotoxic effects on cancer cells resulting from suppression of cell survival signaling.

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ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References

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UCI(KEPA) : I410-ECN-0101-2018-524-001598416