지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.7
- 수록면
- 304 - 308 (5page)
이용수
초록· 키워드
오류제보하기
Background: Joboksansam, Korean bird wild ginseng, is an artificially cultivated wild ginseng germinated from bird feces. Although numerous pharmacologic activities of wild ginsengs have been reported, the beneficial effect of joboksansam in cancer has not been elucidated. In this study, we investigated the in vivo and in vitro anticancer activities of joboksansam powder.
Methods: To evaluate the in vivo anticancer activity of joboksansam, we established a xenograft mouse model bearing RMA cell-derived cancer. Direct cytotoxicity induced by joboksansam powder was also investigated in vitro using (3-4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay. The inhibitory activity of this powder on the activation of cell survival signaling involving Akt and Src was examined with immunoblot analysis.
Results: Joboksansam powder displayed strong inhibitory activity against the increased tumor size, increased weight of total body and cancer tissues, and mortality of tumor-bearing mice. Joboksansam powder also suppressed the activation of survival regulatory enzymes Akt and Src, as assessed by phosphorylation levels in the immunoblot analysis of tumor tissues. Interestingly, the viability of RMA cells in vitro was directly decreased by joboksansam treatment.
Conclusion: Overall, our results strongly suggest that joboksansam powder has the potential to protect against cancer generation by direct cytotoxic effects on cancer cells resulting from suppression of cell survival signaling.
Methods: To evaluate the in vivo anticancer activity of joboksansam, we established a xenograft mouse model bearing RMA cell-derived cancer. Direct cytotoxicity induced by joboksansam powder was also investigated in vitro using (3-4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay. The inhibitory activity of this powder on the activation of cell survival signaling involving Akt and Src was examined with immunoblot analysis.
Results: Joboksansam powder displayed strong inhibitory activity against the increased tumor size, increased weight of total body and cancer tissues, and mortality of tumor-bearing mice. Joboksansam powder also suppressed the activation of survival regulatory enzymes Akt and Src, as assessed by phosphorylation levels in the immunoblot analysis of tumor tissues. Interestingly, the viability of RMA cells in vitro was directly decreased by joboksansam treatment.
Conclusion: Overall, our results strongly suggest that joboksansam powder has the potential to protect against cancer generation by direct cytotoxic effects on cancer cells resulting from suppression of cell survival signaling.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - Yang Y / 2014 / ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract / J Ethnopharmacol 154 : 218 ~ 228
[학술지(정기간행물)] - 이창호 / 2014 / A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases / Journal of Ginseng Research 38 (3) : 161 ~ 166
[기타자료] - Park KT / 2013 / Cultivation method of ginseng sprout / Korea Patent 2013;1013190820000
[학술지(정기간행물)] - Lee JY / 2010 / Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects / J Biol Chem 285 : 9932 ~ 9948
[학술지(정기간행물)] - Yang Y / 2014 / Novel anti-inflammatory function of NSC95397 by the suppression of multiple kinases / Biochem Pharmacol 88 : 201 ~ 215
[학술지(정기간행물)] - 이창호 / 2014 / A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases / Journal of Ginseng Research 38 (3) : 161 ~ 166
[기타자료] - Park KT / 2013 / Cultivation method of ginseng sprout / Korea Patent 2013;1013190820000
[학술지(정기간행물)] - Lee JY / 2010 / Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects / J Biol Chem 285 : 9932 ~ 9948
[학술지(정기간행물)] - Yang Y / 2014 / Novel anti-inflammatory function of NSC95397 by the suppression of multiple kinases / Biochem Pharmacol 88 : 201 ~ 215
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UCI(KEPA) : I410-ECN-0101-2018-524-001598416