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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 556 - 565 (10page)
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초록· 키워드
오류제보하기
Background: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism.
Materials and methods: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs. The rectal, tail, toe, and axilla temperature of the rats were assayed every 3 d. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure were measured via TSE phenoMaster/LabMaster animal monitoring system. Adenosine monophosphate-activated protein kinase, Naþ-Kþ-ATPase, fumarase, pyruvic acid and cyclic adenosine monophosphate/cyclic guanosine monophosphate were determined.
Results: The lower levels of triiodothyronine, tetraiodothyronine, and thyrotropin-releasing hormone and the higher level of thyroid stimulating hormone revealed the successful establishment of a hypothyroidism model. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure in the FZ and RG groups were obviously increased. The activity of Naþ-Kþ-ATPase and fumarase in the FZ and RG groups was significantly increased. The cyclic adenosine monophosphate/cyclic guanosine monophosphate level in the FZ and RG groups was increased, while the GL group showed the opposite.
Conclusion: Our research provides a new way to explore the efficiency of Chinese medicine on the basis of the relationship between drug property and effects on substance and energy metabolism.
Materials and methods: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs. The rectal, tail, toe, and axilla temperature of the rats were assayed every 3 d. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure were measured via TSE phenoMaster/LabMaster animal monitoring system. Adenosine monophosphate-activated protein kinase, Naþ-Kþ-ATPase, fumarase, pyruvic acid and cyclic adenosine monophosphate/cyclic guanosine monophosphate were determined.
Results: The lower levels of triiodothyronine, tetraiodothyronine, and thyrotropin-releasing hormone and the higher level of thyroid stimulating hormone revealed the successful establishment of a hypothyroidism model. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure in the FZ and RG groups were obviously increased. The activity of Naþ-Kþ-ATPase and fumarase in the FZ and RG groups was significantly increased. The cyclic adenosine monophosphate/cyclic guanosine monophosphate level in the FZ and RG groups was increased, while the GL group showed the opposite.
Conclusion: Our research provides a new way to explore the efficiency of Chinese medicine on the basis of the relationship between drug property and effects on substance and energy metabolism.
목차
ABSTRACT
1. Introduction
2. Materials
3. Methods
4. Results
5. Discussion
6. Conclusion
References
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - Kuang H / 2009 / Studies on the capability of properties and flavors of Chinese Medicine to be split and combined-A new assumption on the theory of properties and flavors of Chinese Medicine and the research method / World Sci Technol/Moderniz Trad Chin Med Mater Med 11 : 768 ~ 771
[학술지(정기간행물)] - Park JY / 2016 / Effect of amino acids on the generation of ginsenoside Rg3 epimers by heat processing and the anticancer activities of epimers in A2780 human ovarian cancer cells / Evid Based Compl Alt 3 : 1 ~ 6
[학술지(정기간행물)] - Sharma AM / 2002 / Adipose tissue: a mediator of cardiovascular risk / Int J Obes Relat Metab Disord 4 : S5 ~ S7
[학술지(정기간행물)] - Kong L / 2015 / Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats / J Reprod Dev 61 : 219 ~ 227
[학술지(정기간행물)] - Choksi NY / 2003 / Role of thyroid hormones in human and laboratory animal reproductive health / Birth Defects Res B Dev Reprod Toxicol 68 : 479 ~ 491
[학술지(정기간행물)] - Park JY / 2016 / Effect of amino acids on the generation of ginsenoside Rg3 epimers by heat processing and the anticancer activities of epimers in A2780 human ovarian cancer cells / Evid Based Compl Alt 3 : 1 ~ 6
[학술지(정기간행물)] - Sharma AM / 2002 / Adipose tissue: a mediator of cardiovascular risk / Int J Obes Relat Metab Disord 4 : S5 ~ S7
[학술지(정기간행물)] - Kong L / 2015 / Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats / J Reprod Dev 61 : 219 ~ 227
[학술지(정기간행물)] - Choksi NY / 2003 / Role of thyroid hormones in human and laboratory animal reproductive health / Birth Defects Res B Dev Reprod Toxicol 68 : 479 ~ 491
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UCI(KEPA) : I410-ECN-0101-2018-524-001599337