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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 169 - 175 (7page)
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초록· 키워드
오류제보하기
Background: Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo.
Methods: We examined whether KRG can prevent premature hair follicle dystrophy in a human hair follicle organ culture model during treatment with a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC).
Results: 4-HC inhibited human hair growth, induced premature catagen development, and inhibited proliferation and stimulated apoptosis of hair matrix keratinocytes. In addition, 4-HC increased p53 and Bax protein expression and decreased Bcl2 protein expression. Pretreatment with KRG protected against 4-HC-induced hair growth inhibition and premature catagen development. KRG also suppressed 4-HCinduced inhibition of matrix keratinocyte proliferation and stimulation of matrix keratinocyte apoptosis. Moreover, KRG restored 4-HC-induced p53 and Bax/Bcl2 expression.
Conclusion: Overall, our results indicate that KRG may protect against 4-HC-induced premature catagen development through modulation of p53 and Bax/Bcl2 expression.
Methods: We examined whether KRG can prevent premature hair follicle dystrophy in a human hair follicle organ culture model during treatment with a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC).
Results: 4-HC inhibited human hair growth, induced premature catagen development, and inhibited proliferation and stimulated apoptosis of hair matrix keratinocytes. In addition, 4-HC increased p53 and Bax protein expression and decreased Bcl2 protein expression. Pretreatment with KRG protected against 4-HC-induced hair growth inhibition and premature catagen development. KRG also suppressed 4-HCinduced inhibition of matrix keratinocyte proliferation and stimulation of matrix keratinocyte apoptosis. Moreover, KRG restored 4-HC-induced p53 and Bax/Bcl2 expression.
Conclusion: Overall, our results indicate that KRG may protect against 4-HC-induced premature catagen development through modulation of p53 and Bax/Bcl2 expression.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (50)
참고문헌 신청
[학술지(정기간행물)] - Stenn KS / 2001 / Controls of hair follicle cycling / Physiol Rev 81 : 449 ~ 494
[학술지(정기간행물)] - Yeager CE / 2011 / Treatment of chemotherapy-induced alopecia / Dermatol Ther 24 : 432 ~ 442
[학술지(정기간행물)] - Rosman S / 2004 / Cancer and stigma: experience of patients with chemotherapyinduced alopecia / Patient Educ Couns 52 : 333 ~ 339
[학술지(정기간행물)] - Lemieux J / 2008 / Chemotherapy-induced alopecia and effects on quality of life among women with breast cancer: a literature review / Psychooncology 17 : 317 ~ 328
[학술지(정기간행물)] - Trüeb RM / 2009 / Chemotherapy-induced alopecia / Semin Cutan Med Surg 28 : 11 ~ 14
[학술지(정기간행물)] - Yeager CE / 2011 / Treatment of chemotherapy-induced alopecia / Dermatol Ther 24 : 432 ~ 442
[학술지(정기간행물)] - Rosman S / 2004 / Cancer and stigma: experience of patients with chemotherapyinduced alopecia / Patient Educ Couns 52 : 333 ~ 339
[학술지(정기간행물)] - Lemieux J / 2008 / Chemotherapy-induced alopecia and effects on quality of life among women with breast cancer: a literature review / Psychooncology 17 : 317 ~ 328
[학술지(정기간행물)] - Trüeb RM / 2009 / Chemotherapy-induced alopecia / Semin Cutan Med Surg 28 : 11 ~ 14
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UCI(KEPA) : I410-ECN-0101-2018-524-001598249