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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.22 No.4
- 발행연도
- 2017.12
- 수록면
- 285 - 292 (8page)
- DOI
- 10.3746/pnf.2017.22.4.285
이용수
이 논문의 연구 히스토리 (2)
2017
Anti-Obesity Property of Lichen Thamnolia vermicularis Extract in 3T3-L1 Cells and Diet-Induced Obese Mice
Ra-Yeong Choi
,
Ju Ri Ham
,
Jiyoung Yeo
외 5명
Preventive Nutrition and Food Science
2017.12
학술저널
Anti-Obesity Property of Gentiopicroside by Suppressing Adipogenic and Inflammatory Cytokine Gene Expression in 3T3-L1 Cells
Ra-Yeong Choi
,
Ju Ri Ham
,
Sang-Jip Nam
외 4명
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Thamnolia vermicularis (TV) is an edible lichen that is prevalent in the alpine zone of East Asia. This study evaluated the feasibility of using TV acetone extracts as a functional food based on experiments using cell line and obese mice. The cellular triglyceride levels and Oil red O staining of 3T3-L1 cells indicated that TV extracts (5 and 10 μg/mL) dose-dependently suppressed adipocyte differentiation and lipid accumulation compared with the control. The TV extract (0.4%, w/w) in a high-fat diet (HFD) was supplemented to C57BL/6N mice for 12 weeks, and TV extract supplement significantly reduced visceral fat mass and body weight compared with HFD feeding alone. The TV extract also induced significant decreases in serum and hepatic lipids, whereas it increased the serum high-density lipoproteins-cholesterol/total cholesterol ratio and fecal lipids levels. Moreover, the TV extract led to significantly lower homeostasis model assessment of insulin resistance in diet-induced obese mice. Taken together, these results suggest that the TV extract may have anti- obesity effects, including lipid-lowering, and it is a natural resource with the potential for use in obesity management.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
Dietz WH, Baur LA, Hall K, Puhl RM, Taveras EM, Uauy R, Kopelman P. 2015. Management of obesity: improvement of health-care training and systems for prevention and care. Lancet 385: 2521-2533.
Kushner RF, Ryan DH. 2014. Assessment and lifestyle management of patients with obesity: clinical recommendations from systematic reviews. JAMA 312: 943-952.
Ho JN, Jang JY, Yoon HG, Kim Y, Kim S, Jun W, Lee J. 2012. Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes. J Sci Food Agric 92: 1833- 1840.
Oksanen I. 2006. Ecological and biotechnological aspects of lichens. Appl Microbiol Biotechnol 73: 723-734.
Dias DA, Urban S, Roessner U. 2012. A historical overview of natural products in drug discovery. Metabolites 2: 303-336.
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UCI(KEPA) : I410-ECN-0101-2018-594-001729140