지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 31 - 39 (9page)
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초록· 키워드
오류제보하기
The objective of this study was to evaluate the antioxidant and anti-aging effects of marigold methanol extract (MGME) in human dermal fibroblasts. Total polyphenolic and flavonoid contents in MGME were 74.8 mg TAE (tannic acid equivalent)/g and 85.6 mg RE (rutin equivalent)/g, respectively. MGME (500 μg/mL) increased 1,1- diphenyl-2-picryl hydrazyl (DPPH) and 2,2"-azino-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical-scavenging, and superoxide dismutase (SOD)-like antioxidant activities by 36.5, 54.7, and 14.8%, respectively, compared with the control. At 1,000 μg/mL, these activities increased by 63.7, 70.6, and 20.6%, respectively. MGME (100 μg/mL) significantly increased the synthesis of type 1 procollagen by 83.7% compared with control treatment. It also significantly decreased Matrix Metalloproteinase-2 (MMP-2) activity and MMP-1 mRNA expression by 36.5% and 69.5%, respectively; however, it significantly increased laminin-5 mRNA expression by 181.2%. These findings suggest that MGME could protect human skin against photo-aging by attenuating oxidative damage, suppressing MMP expression and/or activity as well as by stimulating collagen synthesis.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (39)
참고문헌 신청
Brennan, M. / 2003 / Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin / Photochem. Photobiol. 78:43~48
Inomata, S. / 2003 / Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse / J. Invest. Dermatol. 120:128~134
Buechner, N. / 2008 / Changes of MMP-1 and collagen type I alpha1 by UVA, UVB and IRA are differentially regulated by Trx-1 / Exp. Gerontol. 43:633~637
Dong, K.K. / 2008 / UV-induced DNA damage initiates release of MMP-1 in human skin / Exp. Dermatol. 17:1037~1044
Amano, S. / 2005 / Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoaging process / Br. J. Dermatol. 153:37~46
Inomata, S. / 2003 / Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse / J. Invest. Dermatol. 120:128~134
Buechner, N. / 2008 / Changes of MMP-1 and collagen type I alpha1 by UVA, UVB and IRA are differentially regulated by Trx-1 / Exp. Gerontol. 43:633~637
Dong, K.K. / 2008 / UV-induced DNA damage initiates release of MMP-1 in human skin / Exp. Dermatol. 17:1037~1044
Amano, S. / 2005 / Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoaging process / Br. J. Dermatol. 153:37~46
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UCI(KEPA) : I410-ECN-0101-2018-513-001743718