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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 309 - 319 (11page)
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The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor (IC50) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology – Jadavpur University – India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.
목차
Abstract
I. Introduction
II. Softwares and Methods
III. RESULTS
IV. Conclusions
References
참고문헌 (18)
참고문헌 신청
[학술지(정기간행물)] - T. Q. Than / 2004 / Metabolic syndrome / Journal of Cardiology Information 21 (9) : 1 ~ 5
[단행본] - L. X. Truong / 2015 / Clinical biochemistry / Medical Publishers
[학술지(정기간행물)] - Salih J. Wakil / 2009 / Fatty acid metabolism: target for metabolic syndrome / Journal of Lipid Research 50 (Supplement) : S138 ~ S143
[학술지(정기간행물)] - Timothy H. Tran / 2015 / Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase / Nature 518 (7537) : 120 ~ 124
[학술지(정기간행물)] - L. Tong / 2005 / Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery / Cellular and Molecular Life Sciences 62 (16) : 1784 ~ 1803
[단행본] - L. X. Truong / 2015 / Clinical biochemistry / Medical Publishers
[학술지(정기간행물)] - Salih J. Wakil / 2009 / Fatty acid metabolism: target for metabolic syndrome / Journal of Lipid Research 50 (Supplement) : S138 ~ S143
[학술지(정기간행물)] - Timothy H. Tran / 2015 / Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase / Nature 518 (7537) : 120 ~ 124
[학술지(정기간행물)] - L. Tong / 2005 / Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery / Cellular and Molecular Life Sciences 62 (16) : 1784 ~ 1803
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UCI(KEPA) : I410-ECN-0101-2018-056-001660881