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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 376 - 383 (8page)
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초록· 키워드
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Background: Panax ginseng has a wide range of biological activities including anti-inflammatory, antioxidant, and immunomodulatory functions. Wild ginseng cambial meristematic cells (CMCs) were obtained from P. ginseng cambium. This study examined the protective mechanism of wild ginseng CMCs against D-galactosamine (GalN)-induced liver injury. GalN, a well-known hepatotoxicant, causes severe hepatocellular inflammatory damage and clinical features similar to those of human viral hepatitis in experimental animals.
Methods: Hepatotoxicity was induced in rats using GalN (700 mg/kg, i.p.). Wild ginseng CMCs was administered orally once a day for 2 wks, and then 2 h prior to and 6 h after GalN injection. Results: Wild ginseng CMCs attenuated the increase in serum aminotransferase activity that occurs 24 h after GalN injection. Wild ginseng CMCs also attenuated the GalN-induced increase in serum tumor necrosis factor-α, interleukin-6 level, and hepatic cyclooxygenase-2 protein and mRNA expression. Wild ginseng CMCs augmented the increase in serum interleukin -10 and hepatic heme oxygenase-1 protein and mRNA expression that was induced by GalN, inhibited the increase in the nuclear level of nuclear factor-kappa B, and enhanced the increase in NF-E2-related factor 2.
Conclusion: Our findings suggest that wild ginseng CMCs protects liver against GalN-induced inflammation by suppressing proinflammatory mediators and enhancing production of anti-inflammatory mediators.
Methods: Hepatotoxicity was induced in rats using GalN (700 mg/kg, i.p.). Wild ginseng CMCs was administered orally once a day for 2 wks, and then 2 h prior to and 6 h after GalN injection. Results: Wild ginseng CMCs attenuated the increase in serum aminotransferase activity that occurs 24 h after GalN injection. Wild ginseng CMCs also attenuated the GalN-induced increase in serum tumor necrosis factor-α, interleukin-6 level, and hepatic cyclooxygenase-2 protein and mRNA expression. Wild ginseng CMCs augmented the increase in serum interleukin -10 and hepatic heme oxygenase-1 protein and mRNA expression that was induced by GalN, inhibited the increase in the nuclear level of nuclear factor-kappa B, and enhanced the increase in NF-E2-related factor 2.
Conclusion: Our findings suggest that wild ginseng CMCs protects liver against GalN-induced inflammation by suppressing proinflammatory mediators and enhancing production of anti-inflammatory mediators.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (34)
참고문헌 신청
[학술지(정기간행물)] - Bernal W / 2010 / Acute liver failure / Lancet 376 : 190 ~ 201
[학술지(정기간행물)] - Decker K / 1974 / Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. / Rev Physiol Biochem Pharmacol 71 : 77 ~ 106
[학술지(정기간행물)] - Ghosh M / 2012 / D(þ) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-kappaB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin / Free Radic Res 46 : 116 ~ 132
[학술지(정기간행물)] - Immenschuh S / 2010 / Heme oxygenase-1 and iron in liver inflammation: a complex alliance / Curr Drug Targets 11 : 1541 ~ 1550
[학술지(정기간행물)] - Shukla R / 2009 / Role of Panax ginseng as an antioxidant after cadmiuminduced hepatic injuries / Food Chem Toxicol 47 : 769 ~ 773
[학술지(정기간행물)] - Decker K / 1974 / Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. / Rev Physiol Biochem Pharmacol 71 : 77 ~ 106
[학술지(정기간행물)] - Ghosh M / 2012 / D(þ) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-kappaB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin / Free Radic Res 46 : 116 ~ 132
[학술지(정기간행물)] - Immenschuh S / 2010 / Heme oxygenase-1 and iron in liver inflammation: a complex alliance / Curr Drug Targets 11 : 1541 ~ 1550
[학술지(정기간행물)] - Shukla R / 2009 / Role of Panax ginseng as an antioxidant after cadmiuminduced hepatic injuries / Food Chem Toxicol 47 : 769 ~ 773
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UCI(KEPA) : I410-ECN-0101-2018-524-001597979