지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.10
- 수록면
- 251 - 255 (5page)
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초록· 키워드
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Background: Ginsenoside Rp1 (G-Rp1) is a novel ginsenoside derived from ginsenoside Rk1. This compound was reported to have anticancer, anti-platelet, and anti-inflammatory activities. In this study, we examined the molecular target of the antiproliferative and proapoptotic activities of G-Rp1.
Methods: To examine the effects of G-Rp1, cell proliferation assays, propidium iodine staining, proteomic analysis by two-dimensional gel electrophoresis, immunoblotting analysis, and a knockdown strategy were used.
Results: G-Rp1 dose-dependently suppressed the proliferation of colorectal cancer LoVo cells and increased their apoptosis. G-Rp1 markedly upregulated the protein level of apolipoprotein (Apo)-A1 in LoVo, SNU-407, DLD-1, SNU-638, AGS, KPL-4, and SK-BR-3 cells. The knockdown of Apo-A1 by its smallinterfering RNA increased the levels of cleaved poly(ADP-ribose) polymerase and p53 and diminished the proliferation of LoVo cells.
Conclusion: These results suggest that G-Rp1 may act as an anticancer agent by strongly inhibiting cell proliferation and enhancing apoptosis through upregulation of Apo-A1.
Methods: To examine the effects of G-Rp1, cell proliferation assays, propidium iodine staining, proteomic analysis by two-dimensional gel electrophoresis, immunoblotting analysis, and a knockdown strategy were used.
Results: G-Rp1 dose-dependently suppressed the proliferation of colorectal cancer LoVo cells and increased their apoptosis. G-Rp1 markedly upregulated the protein level of apolipoprotein (Apo)-A1 in LoVo, SNU-407, DLD-1, SNU-638, AGS, KPL-4, and SK-BR-3 cells. The knockdown of Apo-A1 by its smallinterfering RNA increased the levels of cleaved poly(ADP-ribose) polymerase and p53 and diminished the proliferation of LoVo cells.
Conclusion: These results suggest that G-Rp1 may act as an anticancer agent by strongly inhibiting cell proliferation and enhancing apoptosis through upregulation of Apo-A1.
목차
abstract
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - 이봄비 / 2013 / Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments by Anti-Inflammatory Activity in Rats / Biomolecules & Therapeutics 21 (5) : 381 ~ 390
2. [학술지(정기간행물)] - 유영춘 / 2013 / Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice / Journal of Ginseng Research 37 (1) : 80 ~ 86
3. [학술지(정기간행물)] - Cho JY / 2001 / vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists / Planta Med 67 : 213 ~ 218
4. [학술지(정기간행물)] - Kumar A / 2006 / Evaluation of chemopreventive action of Ginsenoside Rp1 / Biofactors 26 : 29 ~ 43
5. [학술지(정기간행물)] - Park TY / 2008 / Anti-metastatic potential of ginsenoside Rp1, a novel ginsenoside derivative / Biol Pharm Bull 31 : 1802 ~ 1805
2. [학술지(정기간행물)] - 유영춘 / 2013 / Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice / Journal of Ginseng Research 37 (1) : 80 ~ 86
3. [학술지(정기간행물)] - Cho JY / 2001 / vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists / Planta Med 67 : 213 ~ 218
4. [학술지(정기간행물)] - Kumar A / 2006 / Evaluation of chemopreventive action of Ginsenoside Rp1 / Biofactors 26 : 29 ~ 43
5. [학술지(정기간행물)] - Park TY / 2008 / Anti-metastatic potential of ginsenoside Rp1, a novel ginsenoside derivative / Biol Pharm Bull 31 : 1802 ~ 1805
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UCI(KEPA) : I410-ECN-0101-2018-524-001597439