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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 33 - 52 (20page)
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초록· 키워드
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The initiation of cellular antiviral signaling depends on host pattern-recognition receptors (PRRs)-mediated recognition of viral nucleic acids that are known as classical pathogenassociated molecular patterns (PAMPs). PRRs recruit adaptor proteins and kinases to activate transcription factors and epigenetic modifiers to regulate transcription of hundreds of genes, the products of which collaborate to elicit antiviral responses. In addition, PRRs-triggered signaling induces activation of various inflammasomes which leads to the release of IL-1β and inflammation. Recent studies have demonstrated that PRRs-triggered signaling is critically regulated by ubiquitin and ubiquitin-like molecules. In this review, we first summarize an updated understanding of cellular antiviral signaling and virus-induced activation of inflammasome and then focus on the regulation of key components by ubiquitin and ubiquitin-like molecules.
목차
ABSTRACT
INTRODUCTION
VIRUS-TRIGGERED PRRS-MEDIATED SIGNALING
REGULATION OF VIRUS-TRIGGERED PRRS-MEDIATEDSIGNALING
UBIQUITINATION AND DEUBIQUITINATION
SUMOYLATION AND DE-SUMOYLATION
ISGYLATION AND DE-ISGYLATION
NEDDYLATION AND DE-NEDDYLATION
CONCLUDING REMARKS
REFERENCES
참고문헌 (141)
참고문헌 신청
Janeway CA Jr / 1989 / Approaching the asymptote? Evolution and revolution in immunology / Cold Spring Harb Symp Quant Biol 54:1~13
Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140:805~820
Wu J / 2014 / Innate immune sensing and signaling of cytosolic nucleic acids / Annu Rev Immunol 32:461~488
Kawai T / 2005 / IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction / Nat Immunol 6:981~988
Meylan E / 2005 / Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus / Nature 437:1167~1172
Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140:805~820
Wu J / 2014 / Innate immune sensing and signaling of cytosolic nucleic acids / Annu Rev Immunol 32:461~488
Kawai T / 2005 / IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction / Nat Immunol 6:981~988
Meylan E / 2005 / Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus / Nature 437:1167~1172
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UCI(KEPA) : I410-ECN-0101-2018-517-001801140