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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 113 - 128 (16page)
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초록· 키워드
오류제보하기
Emerging evidence demonstrates that the microbiota plays an essential role in shaping the development and function of host immune responses. A variety of environmental stimuli, including foods and commensals, are recognized by the host through the epithelium, acting as a physical barrier. Two allergic diseases, atopic dermatitis and food allergy, are closely linked to the microbiota, because inflammatory responses occur on the epidermal border. The microbiota generates metabolites such as short-chain fatty acids and poly-γ-glutamic acid (γPGA), which can modulate host immune responses. Here, we review how microbial metabolites can regulate allergic immune responses. Furthermore, we focus on the effect of γPGA on allergic T helper (Th) 2 responses and its therapeutic application.
목차
ABSTRACT
INTRODUCTION
IMMUNE EFFECTORS IN AD AND FA
ROLES OF THE MICROBIOTA AND ITS METABOLITES INALLERGIC IMMUNE RESPONSES
IMMUNOLOGICAL LINK BETWEEN AD AND FA
TH1/TH2 REGULATION OF ALLERGIC DISEASES
EFFECT OF THE MICROBIOTA AND ITS METABOLITES ONTH1/TH2 BALANCE
EFFECT OF THE MICROBIOTA AND ITS METABOLITES ONTREG/TH2 BALANCE
CONCLUSION
REFERENCES
참고문헌 (102)
참고문헌 신청
Marenholz I / 2017 / Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy / Nat Commun 8:1056
van Ginkel CD / 2015 / Loss-of-function variants of the filaggrin gene are associated with clinical reactivity to foods / Allergy 70:461~464
Brandt EB / 2011 / Th2 cytokines and atopic dermatitis / J Clin Cell Immunol 2:110
Imai Y / 2013 / Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice / Proc Natl Acad Sci U S A 110:13921~13926
Seneschal J / 2012 / Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells / Immunity 36:873~884
van Ginkel CD / 2015 / Loss-of-function variants of the filaggrin gene are associated with clinical reactivity to foods / Allergy 70:461~464
Brandt EB / 2011 / Th2 cytokines and atopic dermatitis / J Clin Cell Immunol 2:110
Imai Y / 2013 / Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice / Proc Natl Acad Sci U S A 110:13921~13926
Seneschal J / 2012 / Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells / Immunity 36:873~884
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UCI(KEPA) : I410-ECN-0101-2018-517-001801195