지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 75 - 79 (5page)
- DOI
- 10.15188/kjopp.2018.02.32.1.75
이용수
초록· 키워드
오류제보하기
Animal models of atopic dermatitis (AD) are widely used to investigate therapeutic effects of candidates for AD. However, the characteristics of each model are not fully understood. This study was designed to compare the animal models of dermatitis induced by dinitrofluorobenzene (DNFB) and oxazolone (Ox). We investigated the effects of DNFB and Ox on skin thicknesses and weights as well as skin lesions associated with AD such as scale, crust and erythematous eruption, and histopathological changes such as hyperkeratosis, dermal and epidermal hyperplasia and immune cell infiltration in inflamed tissues. Multiple application of 0.5% Ox onto the skin increased skin thickness and weight compared to those of DNFB treated mice, as well as those of normal mice. In addition, topical application of DNFB induced marked scale, crust and erythematous eruption, while Ox induced erythematous eruption and mild scale and crust. Histopathological examination revealed that 0.5% Ox induced marked hyperplasia in the dermis and epidermis, large vesicles, spongiotic changes, mild hyperkeratosis and immune cell infiltration in balb/c mice. These data suggest that multiple applications of Ox can induce chronic AD like dermatitis in balb/c mice.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (14)
참고문헌 신청
[학술지(정기간행물)] - Tanaka A / 2012 / Recent findings in mouse models for human atopic dermatitis / Exp Anim 61 (2) : 77 ~ 84
[학술지(정기간행물)] - Jin H / 2009 / Animal models of atopic dermatitis / J Invest Dermatol 129 (1) : 31 ~ 40
[학술지(정기간행물)] - Christensen AD / 2012 / Immunological mechanisms of contact hypersensitivity in mice / APMIS 120 (1) : 1 ~ 27
[학술지(정기간행물)] - Man MQ / 2008 / Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges / J Invest Dermatol 128 (1) : 79 ~ 86
[학술지(정기간행물)] - Han HY / 2015 / Effects of Dictamnus dasycarpus Turcz., root bark on ICAM-1 expression and chemokine productions in vivo and vitro study / J Ethnopharmacol 159 : 245 ~ 252
[학술지(정기간행물)] - Jin H / 2009 / Animal models of atopic dermatitis / J Invest Dermatol 129 (1) : 31 ~ 40
[학술지(정기간행물)] - Christensen AD / 2012 / Immunological mechanisms of contact hypersensitivity in mice / APMIS 120 (1) : 1 ~ 27
[학술지(정기간행물)] - Man MQ / 2008 / Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges / J Invest Dermatol 128 (1) : 79 ~ 86
[학술지(정기간행물)] - Han HY / 2015 / Effects of Dictamnus dasycarpus Turcz., root bark on ICAM-1 expression and chemokine productions in vivo and vitro study / J Ethnopharmacol 159 : 245 ~ 252
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UCI(KEPA) : I410-ECN-0101-2018-519-001809191