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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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μMT knockout mice are genetically deficient in the transmembrane domain of mu chain of the immunoglobulin M (IgM) heavy chain, resulting in the absence of mature B cells. μMT knockout mice is an in vivo model system used to clarify the role of B cells in various diseases. Enteropathogenic Escherichia coli (EPEC) induces acute and chronic diarrheal disease, especially in children of developing countries. The formation of attaching and effacing (A/E) lesion is a prominent pathogenic factor in the intestinal epithelium of EPEC infection. The A/E lesion is modulated by genes located on the pathogenic island locus of enterocyte effacement (LEE) which encode a type III secretion system (T3SS) and A/E lesion-related effector proteins. Citrobacter rodentium is a murine pathogen utilized in studying the pathogenic mechanisms of EPEC in human infections. Citrobacter rodentium produce A/E lesion to attach to intestinal epithelium, thus providing a murine model pathogen to study EPEC. Several studies have investigated the pathogenesis of Citrobacter rodentium in the μMT knockout mice. In this review, we introduce the μMT murine model in the context of C. rodentium pathogenesis and describe in detail the role of B cells and antibodies in this disease.
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서론
본론
결론
REFERENCES
참고문헌 (53)
참고문헌 신청
Barthold SW / 1978 / Transmissible murine colonic hyperplasia / Veterinary Pathology 15:223~236
Behiry IK / 2011 / Enteropathogenic Escherichia coli associated with diarrhea in children in Cairo, Egypt / The Scientific World Journal 11:2613~2619
Bry L / 2004 / Critical role of t cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen / The Journal of Immunology 172:433~441
Cerutti A / 2011 / Immunoglobulin responses at the mucosal interface / Annual Review of Immunology 29:273~293
Chen HD / 2005 / Enteropathogenic Escherichia coli: unravelling pathogenesis / FEMS Microbiology Reviews 29:83~98
Behiry IK / 2011 / Enteropathogenic Escherichia coli associated with diarrhea in children in Cairo, Egypt / The Scientific World Journal 11:2613~2619
Bry L / 2004 / Critical role of t cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen / The Journal of Immunology 172:433~441
Cerutti A / 2011 / Immunoglobulin responses at the mucosal interface / Annual Review of Immunology 29:273~293
Chen HD / 2005 / Enteropathogenic Escherichia coli: unravelling pathogenesis / FEMS Microbiology Reviews 29:83~98
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UCI(KEPA) : I410-ECN-0101-2018-510-001903491