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논문 기본 정보

자료유형
학술저널
저자정보
Jin-Ha Yoon (Yonsei University College of Medicine) Woo Seok Kwak (Yonsei University College of Medicine) Yeon-Soon Ahn (Yonsei University Wonju College of Medicine)
저널정보
대한직업환경의학회 대한직업환경의학회지 대한직업환경의학회지 제30권 제3호
발행연도
2018.5
수록면
88 - 92 (5page)

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We reviewed articles to clarify the current evidence status for 1) types of cancer which related to benzene exposure, and 2) certain benzene exposure level which might cause the hematopoietic cancers. Hematopoietic function of the bone marrow is involved in the production of all blood cells types. The benzene metabolites including benzoquinone and mucoaldehyde affect hematopoietic stem cells as well as differentiation steps of progenitor cells for each blood cell. Hence, we concluded that benzene was associated with all lymphohematic carcinogenesis. First, it is supported by biological plausibility. Second, it is supported by meta-analysis although sing study did not show relationship due to lack of sample size or statistical power. More recent studies show lesser exposed level related to risk of cancer, compare to past studies did. Actually, early studies show the risk of malignancies in workers who exposed more than 200 ppm-years. However, only 0.5 to 1 ppm-year benzene exposed show significant linking to risk of malignancies in recent study. As reviewed research articles, we concluded that the relatively lower exposure level, such as 0.5-1 ppm-year, will be considering at risk of hematopoietic cancer. However, more research needs to be done on dose-response analysis.

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UCI(KEPA) : I410-ECN-0101-2018-517-002066563