지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 124 - 129 (6page)
이용수
초록· 키워드
오류제보하기
PC12 neuronal cell-protective effects of hot water extracts of guava fruit and leaf were evaluated. Total phenolic levels in fruit and leaf were 11.75 and 293.25 mg/g, respectively. Gallic acid, the predominant phenoic, was detected in both extracts. Intracellular reactive oxygen species (ROS) accumulation after H<sub>2</sub>O<SUB>2</SUB> treatment was significantly reduced when the hot water extract of guava leaf was added to cell medium, compared to PC12 cells treated with H<sub>2</sub>O<SUB>2</SUB> only. In a cell viability assay using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl- tetrazoliumbromide (MTT), the hot water extracts of fruit and leaf protected against H<sub>2</sub>O<SUB>2</SUB>-induced neurotoxicity. The leaf extract was more effective in terms of inhibition of lactate dehydrogenase (LDH) release into medium, compared to the fruit extract. These in vitro data suggest that hot water extracts of guava fruit and leaf may be useful in treatment of neurodegenerative conditions such as Alzheimer`s disease.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Runyons CR / 2005 / Antioxidants for prevention of dementia : overview of the pre-advise trial / Alzheimer's Dementia 1 : 74 ~
2. [학술지(정기간행물)] - Behl C / 1999 / Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches / Prog Neurobiol 57 : 301 ~ 323
3. [학술지(정기간행물)] - Ames BN / 1993 / Oxidant, antioxidants, and the degenerative disease of aging / Proc Natl Acad Sci USA 90 : 7915 ~ 7922
4. [학술지(정기간행물)] - Heo HJ / 2008 / Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC 12 cells / J FOOD SCI 73 (2) : H28 ~ H32
5. [학술지(정기간행물)] - Begum S / 2002 / Triterpenoids from the leaves of Psidium guajava / Phytochemistry 61 : 399 ~ 403
2. [학술지(정기간행물)] - Behl C / 1999 / Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches / Prog Neurobiol 57 : 301 ~ 323
3. [학술지(정기간행물)] - Ames BN / 1993 / Oxidant, antioxidants, and the degenerative disease of aging / Proc Natl Acad Sci USA 90 : 7915 ~ 7922
4. [학술지(정기간행물)] - Heo HJ / 2008 / Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC 12 cells / J FOOD SCI 73 (2) : H28 ~ H32
5. [학술지(정기간행물)] - Begum S / 2002 / Triterpenoids from the leaves of Psidium guajava / Phytochemistry 61 : 399 ~ 403
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-059-003074228