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논문 기본 정보

자료유형
학술저널
저자정보
Xiyuan Bai (University of Colorado Anschutz Medical Center) Shanae L. Aerts (National Jewish Health) Deepshikha Verma (Colorado State University) Diane J. Ordway (Colorado State University) Edward D. Chan (University of Colorado Anschutz Medical Center)
저널정보
대한면역학회 Immune Network Immune Network Vol.18 No.3
발행연도
2018.6
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1 - 19 (19page)

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Many studies have linked cigarette smoke (CS) exposure and tuberculosis (TB) infection and disease although much fewer have studied second-hand smoke (SHS) exposure. Our goal is to review the epidemiologic link between SHS and TB as well as to summarize the effects SHS and direct CS on various immune cells relevant for TB. PubMed searches were performed using the key words “tuberculosis” with “cigarette,” “tobacco,” or “second-hand smoke.” The bibliography of relevant papers were examined for additional relevant publications. Relatively few studies associate SHS exposure with TB infection and active disease. Both SHS and direct CS can alter various components of host immunity resulting in increased vulnerability to TB. While the epidemiologic link of these 2 health maladies is robust, more definitive, mechanistic studies are required to prove that SHS and direct CS actually cause increased susceptibility to TB.

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ABSTRACT
INTRODUCTION
METHODS
EPIDEMIOLOGIC STUDIES LINKING SHS EXPOSURE WITH TB INFECTION AND DISEASE
MURINE STUDIES ON SHS/DIRECT CS AND TB
THE EFFECTS OF SHS/DIRECT CS EXPOSURE ON IMMUNE CELLS RELEVANT FOR TB
CAN CS ENHANCE MTB VIRULENCE?
SUMMARY
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2018-517-003105474