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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.2
- 발행연도
- 2018.6
- 수록면
- 122 - 126 (5page)
- DOI
- 10.3746/pnf.2018.23.2.122
이용수
초록· 키워드
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In this study, we investigated the postprandial hypoglycemic effect of Sargassum sagamianum extract (SSE) in streptozotocin-induced diabetic mice. Freeze-dried S. sagamianum was extracted with 80% ethanol and concentrated. The inhibition of postprandial hyperglycemia was determined by the inhibitory activity against α-glucosidase and α-amylase as well as the measurement of postprandial blood glucose levels. SSE demonstrated a high inhibitory activity against α-glucosidase and α-amylase. The IC<SUB>50</SUB> value of SSE against α-glucosidase and α-amylase was 0.095 mg/mL and 0.199 mg/mL, respectively, and thus it was significantly more efficacious than the pharmaceutical acarbose (0.115 mg/mL and 0.229 mg/mL, respectively). The postprandial blood glucose levels in the SSE-administered group were significantly lower than those in the control group. Furthermore, the area under the curve significantly decreased following the administration of SSE. These results indicate that SSE can be used as an α-glucosidase and α-amylase inhibitor and can delay the absorption of dietary carbohydrates.
목차
ABSTRACT
NTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - Toobaei Z / 2015 / Synthesis of novel poly-hydroxyl functionalized acridine derivatives as inhibitors of ${\alpha}$ -glucosidase and ${\alpha}$ -amylase / Carbohydr Res 411 : 22 ~ 32
[학술지(정기간행물)] - Cade WT / 2008 / Diabetes-related microvascular and macrovascular diseases in the physical therapy setting / Phys Ther 88 : 1322 ~ 1335
[학술지(정기간행물)] - Chinenye S / 2012 / Isolated postprandial hyperglycemia in type 2 diabetic patients in a Nigerian Tertiary Health Center / Indian J Endocrinol Metab 16 : 604 ~ 608
[학술지(정기간행물)] - Haffner SM / 1998 / The importance of hyperglycemia in the nonfasting state to the development of cardiovascular disease / Endocr Rev 19 : 583 ~ 592
[학술지(정기간행물)] - Lee SH / 2014 / Octaphlorethol A: a potent ${\alpha}$ -glucosidase inhibitor isolated from Ishige foliacea shows an anti-hyperglycemic effect in mice with streptozotocin-induced diabetes / Food Funct 5 : 2602 ~ 2608
[학술지(정기간행물)] - Cade WT / 2008 / Diabetes-related microvascular and macrovascular diseases in the physical therapy setting / Phys Ther 88 : 1322 ~ 1335
[학술지(정기간행물)] - Chinenye S / 2012 / Isolated postprandial hyperglycemia in type 2 diabetic patients in a Nigerian Tertiary Health Center / Indian J Endocrinol Metab 16 : 604 ~ 608
[학술지(정기간행물)] - Haffner SM / 1998 / The importance of hyperglycemia in the nonfasting state to the development of cardiovascular disease / Endocr Rev 19 : 583 ~ 592
[학술지(정기간행물)] - Lee SH / 2014 / Octaphlorethol A: a potent
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UCI(KEPA) : I410-ECN-0101-2018-594-003146218