지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 81 - 87 (7page)
이용수
초록· 키워드
오류제보하기
Thapsigargin (TGN) is a potent and selective inhibitor of sarco-endoplasmic Ca<SUP>2+</SUP>-ATPase, leading to rapid elevation of cytoplasmic Ca<SUP>2+</SUP> concentration. Previous reports have shown that TGN increases the production of various cytokines from macrophages and dendritic cells. Here, we examine the effects of TGN on murine T cells. Nanomolar concentrations of TGN are a significant inducer of IL-2 production with full activity at 50 nM. Micromolar concentrations of TGN, however, are inhibitory to IL-2 production and T cell proliferation. The IL-2 production-inducing activity of TGN is much more prominent when T cells are primed with concanavalin A or anti-CD3 mAb, and is due to the increase of cytoplasmic Ca<SUP>2+</SUP> concentration. TGN at 50 nM does not affect interferon-gamma or IL-4 production from T cells. Thus, the present study shows that low nanomolar concentrations of TGN could be useful in potentiating IL-2 production from antigen-primed T cells.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
Oh-hora M / 2008 / Calcium signaling in lymphocytes / Curr Opin Immunol 20:250~258
Fracchia KM / 2013 / Modulation of T cell metabolism and function through calcium signaling / Front Immunol 4:324
Akerman KE / 1984 / Direct mitogenic effect of ionophore A23187 on isolated human T helper lymphocytes / Eur J Immunol 14:286~288
Truneh A / 1985 / Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester / Nature 313:318~320
Ai W / 2013 / Optimal method to stimulate cytokine production and its use in immunotoxicity assessment / Int J Environ Res Public Health 10:3834~3842
Fracchia KM / 2013 / Modulation of T cell metabolism and function through calcium signaling / Front Immunol 4:324
Akerman KE / 1984 / Direct mitogenic effect of ionophore A23187 on isolated human T helper lymphocytes / Eur J Immunol 14:286~288
Truneh A / 1985 / Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester / Nature 313:318~320
Ai W / 2013 / Optimal method to stimulate cytokine production and its use in immunotoxicity assessment / Int J Environ Res Public Health 10:3834~3842
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Sequestration of sorcin by aberrant forms of tau results in the defective calcium homeostasis
The Korean Journal of Physiology & Pharmacology
2016 .07
-
Research on Epstein-Barr virus immunity using a mouse model: from new insights to cancer immunotherapeutic applications
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
[S6-1] Advancing Vivarium Efficiency and Animal Welfare through Digitalization: the Scientific advantages of the DVC® System
한국실험동물학회 학술발표대회 논문집
2024 .07
-
Lipoxygenases, Hyaluronidase, and Xanthine Oxidase Inhibitory Effects Extracted from Five Hydrocotyle Species
대한의생명과학회지
2021 .12
-
당귀수산과 삼황사심탕의 혈관이완효과
동의생리병리학회지
2019 .08
-
소아의 실내 · 외 PM10에 따른 응급실 방문 위해도평가
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
통계적 혼합모형을 이용한 몽골 울란바토르 게르 내 PM2.5 농도 증가에 영향을 미치는 주요 요인 선별
보건학논집
2020 .08
-
Mortality and morbidity assessment attributed to short- and long-term exposure to fine particles in ambient air of Agadir city, Morocco: The AirQ model approach
Environmental Analysis Health and Toxicology
2023 .06
-
미세먼지 계절관리제 시행 여부에 따른 실내 PM10, PM2.5 농도 분포 및 건강위해성평가
환경독성보건학회 심포지엄 및 학술대회
2023 .05
-
In vitro acute inhalation toxicity for TiO₂ (GST) using 3D human tissue model (EpiAirwayTM)
Environmental Analysis Health and Toxicology
2021 .09
-
Public awareness and practices towards health impacts of PM2.5 in the Kingdom of Bahrain: identifying areas for intervention
Environmental Analysis Health and Toxicology
2022 .06
-
Long-term Exposure to Ambient Air Pollutants and Early Age-related Macular Degeneration in Middle-aged and Older Adults
환경독성보건학회 심포지엄 및 학술대회
2021 .10
-
Franz Diffusion Cell을 이용한 인진호 함유 경피제의 피부투과 특성 연구
생약학회지(Korean Journal of Pharmacognosy)
2018 .06
-
Inhibitory effects of thromboxane A₂ generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A₂ phosphorylation and arachidonic acid release
Journal of Ginseng Research
2019 .04
-
울산 산업단지 지역 PM2.5 중 이온, 탄소, 원소성분의 특성 연구
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
Association between Long-Term Exposure to Ambient Air Pollutants and Hearing Loss in Korean Adults
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
Identification of a novel triterpene saponin from Panax ginseng seeds, pseudoginsenoside RT8, and its antiinflammatory activity
Journal of Ginseng Research
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-517-003392120