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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.4
- 발행연도
- 2018.12
- 수록면
- 294 - 300 (7page)
- DOI
- 10.3746/pnf.2018.23.4.294
이용수
초록· 키워드
오류제보하기
Probiotics may offer a safe intervention for diarrheal diseases. The aim of the present study was the assessment of the antidiarrheal property of probiotic bacteria. For their antidiarrheal efficacy assessment, yogurt was prepared using the isolated bacteria from selective regional yogurt of Bangladesh, and mice model trails were conducted using castor oil induced diarrheal mice. The probiotic treatment was applied on three mice groups, each having 6 mice and their respective doses were 50 mL/kg body weight in treatment group (TG) 1, 100 mL/kg body weight in TG2, and 150 mL/kg body weight in TG3. A four week treatment of probiotic significantly (P<0.001) reduced the percentage (67.37%) of diarrhea in TG3 (150 mL yogurt/kg body weight). All the treatment groups showed a significant (P<0.001) increase in the latent periods, reduced the total fecal output, and frequency and fecal water content compared to the negative control group. Serum electrolytes (Na<SUP>+</SUP> and K<SUP>+</SUP>) and total protein levels were higher in the TG3 compared to the negative control group. Further research regarding molecular characterization and identification of specific genes and proteins of interest may help to develop the next generation bacteriocins and antidiarrheal drugs.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Pesola GE / 1989 / Isotonic nasogastric tube feedings : do they cause diarrhea? / Crit Care Med 17 : 1151 ~ 1155
[학술지(정기간행물)] - Viall C / 1990 / A double-blind clinical trial comparing the gastrointestinal side effects of two enteral feeding formulas / J Parenter Enteral Nutr 14 : 265 ~ 269
[학술지(정기간행물)] - Thomas C / 2003 / Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea : a systematic review / J Antimicrob Chemother 51 : 1339 ~ 1350
[학술지(정기간행물)] - Talley NJ / 1994 / Self-reported diarrhea : what does it mean? / Am J Gastroenterol 89 : 1160 ~ 1164
[학술지(정기간행물)] - Allen SJ / 2013 / Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients(PLACIDE) : a randomised, double-blind, placebo-controlled, multicentre trial / Lancet 382 : 1249 ~ 1257
[학술지(정기간행물)] - Viall C / 1990 / A double-blind clinical trial comparing the gastrointestinal side effects of two enteral feeding formulas / J Parenter Enteral Nutr 14 : 265 ~ 269
[학술지(정기간행물)] - Thomas C / 2003 / Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea : a systematic review / J Antimicrob Chemother 51 : 1339 ~ 1350
[학술지(정기간행물)] - Talley NJ / 1994 / Self-reported diarrhea : what does it mean? / Am J Gastroenterol 89 : 1160 ~ 1164
[학술지(정기간행물)] - Allen SJ / 2013 / Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients(PLACIDE) : a randomised, double-blind, placebo-controlled, multicentre trial / Lancet 382 : 1249 ~ 1257
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UCI(KEPA) : I410-ECN-0101-2019-594-000300609