Subchronic and Reproductive/Developmental Toxicity Studies of Tetrahydrocurcumin in Rats

Muhammed Majeed; Sankaran Natarajan; Anjali Pandey; Sarang Bani; Lakshmi Mundkur

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자료유형: 학술저널

저자정보: Muhammed Majeed (Sami Labs Limited) Sankaran Natarajan (Sami Labs Limited) Anjali Pandey (Sami Labs Limited) Sarang Bani (Sami Labs Limited) Lakshmi Mundkur (Sami Labs Limited)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.35 No.1

발행연도: 2019.1

수록면: 65 - 74 (10page)

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연구주제

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연구배경

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연구방법

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연구결과

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Tetrahydrocurcumin (THC) is a major metabolite of curcumin, which is obtained from Curcuma longa. THC has various benefits and overcomes the bioavailability issue of curcumin. To establish it as a pharmacologically active molecule, its safety profile has to be determined. Thus, the present study aimed to determine the preclinical safety profile of THC in a 90-day subchronic and reproductive/developmental toxicity study in Wistar rats. THC at oral doses of 100, 200, and 400 mg/kg was administered daily for 90 days. Rats in the recovery group were kept for 14 days after treatment termination. The animals were observed for treatment-related morbidity, mortality, and changes in clinical signs, clinical pathology, and histopathology. In the reproductive/developmental toxicity study, THC at 100, 200, and 400 mg/kg was administered orally to rats and the reproductive/developmental parameters in adult male and female rats and pups were observed. THC at up to 400 mg/kg/day of did not have any significant effect on all parameters in male and female rats in both toxicity studies. Thus, 400 mg/kg/day can be considered as the no-observed-adverse-effect-level of THC in rats.

#Tetrahydrocurcumin #Toxicity #Subchronic #Reproductive/developmental

참고문헌 (29)

참고문헌 신청

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