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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.45 No.4
- 발행연도
- 2018.12
- 수록면
- 761 - 767 (7page)
이용수
초록· 키워드
오류제보하기
Degenerative diseases are commonly associated with excess free radicals. Acer okamotoanum, a plant endemic to Korea, is reported to have anti-oxidant, anti-cancer, and anti-viral activities. We previously isolated flavonoids from the ethyl acetate fraction of A. okamotoanum such as quercitrin (QU), isoquercitrin (IQ), and afzelin (AF). In the present study, the in vitro antioxidant activity of flavonoids such as QU, IQ, and AF isolated from the ethyl acetate fraction of A. okamotoanum were investigated by measuring the free radical scavenging activity including 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical (<SUP>•</SUP><SUP></SUP>OH), and superoxide anion (O₂<SUP>-</SUP>). The flavonoids (QU, IQ, and AF) concentration-dependently showed a DPPH radical scavenging activity. In particular, QU and IQ showed a higher DPPH radical scavenging activity than that of AF. In addition, the flavonoids (QU, IQ, and AF) at 10 μg/mL showed over an 80% scavenging effect against <SUP>•</SUP>OH radical production. Furthermore, the O₂<SUP>-</SUP> radical scavenging activity of the flavonoids, QU, IQ, and AF increased in a dose-dependent manner. Particularly, IQ exerted the strongest scavenging activities against <SUP>•</SUP>OH and O₂<SUP>-</SUP> radicals among the other flavonoids. These results indicate that the flavonoids from A. okamotoanum, in particular IQ, would have a protective activity against oxidative stress induced by free radicals, and potentially be considered as a natural antioxidant agent.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - 최수연 / 2017 / Acer okamotoanum improves cognition and memory function in Ab25–35-induced Alzheimer’s mice model / Applied Biological Chemistry 60 (1) : 1 ~ 9
[학술지(정기간행물)] - Di Domenico F / 2015 / Strategy to reduce free radical species in Alzheimer's disease : An update of selected antioxidants / Expert Review of Neurotherapeutics 15 : 19 ~ 40
[학술지(정기간행물)] - Ewing JF / 1995 / Microplate superoxide dismutase assay emplying a nonenzymatic superoxide generator / Analytical Biochemistry 232 : 243 ~ 248
[학술지(정기간행물)] - Gutteridge JM / 1987 / Ferrous-salt-promoted damage to deoxyribose and benzoate. The increased effectiveness of hydroxyl-radical scavengers in the presence of EDTA / Biochemical Journal 243 : 709 ~ 714
[학술지(정기간행물)] - Habu JB / 2015 / In vitro antioxidant capacity and free radical scavenging evaluation of active metabolite constituents of Newbouldia laevis ethanolic leaf extract / Biological Research 48 : 16 ~
[학술지(정기간행물)] - Di Domenico F / 2015 / Strategy to reduce free radical species in Alzheimer's disease : An update of selected antioxidants / Expert Review of Neurotherapeutics 15 : 19 ~ 40
[학술지(정기간행물)] - Ewing JF / 1995 / Microplate superoxide dismutase assay emplying a nonenzymatic superoxide generator / Analytical Biochemistry 232 : 243 ~ 248
[학술지(정기간행물)] - Gutteridge JM / 1987 / Ferrous-salt-promoted damage to deoxyribose and benzoate. The increased effectiveness of hydroxyl-radical scavengers in the presence of EDTA / Biochemical Journal 243 : 709 ~ 714
[학술지(정기간행물)] - Habu JB / 2015 / In vitro antioxidant capacity and free radical scavenging evaluation of active metabolite constituents of Newbouldia laevis ethanolic leaf extract / Biological Research 48 : 16 ~
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UCI(KEPA) : I410-ECN-0101-2019-520-000313599