지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Metformin is a drug used for the treatment of diabetes and is associated with anti-inflammatory reaction, but the underlying mechanism is unclear. In this study, we investigated the effect of metformin on the inflammatory response in BV-2 microglial cells induced by lipopolysaccharide (LPS) and S100 calcium-binding protein A8 (S100A8). The results revealed that metformin significantly attenuated several inflammatory responses in BV-2 microglial cells, including the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin (IL)-6, involved in the activation of Beclin-1, a crucial regulator of autophagy. In addition, metformin inhibited the LPS-induced phosphorylation of ERK. Metformin also suppressed the activation of NOD-like receptor pyrin domain containing 3 inflammasomes composed of NLRP3, caspase-1, and apoptosis-associated speck like protein containing a caspase recruitment domain, which are involved in the innate immune response. Notably, metformin decreased the secretion of S100A8-induced IL-6 production. These findings suggest that metformin alleviates the neuroinflammatory response via autophagy activation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
Abderrazak A / 2015 / Nlrp3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases / Redox Biol 4:296~307
Bauernfeind F / 2009 / Nf-kb activating pattern recognition and cytokine receptors license nlrp3 inflammasome activation by regulating nlrp3 expression / J Immunol 183:787~791
Chen Y / 2009 / Antidiabetic drug metformin (glucophager) increases biogenesis of alzheimer's amyloid peptides via up-regulating bace1 transcription / Proceedings of the National Academy of Sciences 106:3907~3912
Cunha C / 2016 / Exploring new inflammatory biomarkers and pathways during lps-induced m1 polarization / Mediators of Inflammation 2016:1~17
Fan HH / 2017 / Hyperoside inhibits lipopolysaccharideinduced inflammatory responses in microglial cells via p38 and nfkappab pathways / Int Immunopharmacol 50:14~21
Bauernfeind F / 2009 / Nf-kb activating pattern recognition and cytokine receptors license nlrp3 inflammasome activation by regulating nlrp3 expression / J Immunol 183:787~791
Chen Y / 2009 / Antidiabetic drug metformin (glucophager) increases biogenesis of alzheimer's amyloid peptides via up-regulating bace1 transcription / Proceedings of the National Academy of Sciences 106:3907~3912
Cunha C / 2016 / Exploring new inflammatory biomarkers and pathways during lps-induced m1 polarization / Mediators of Inflammation 2016:1~17
Fan HH / 2017 / Hyperoside inhibits lipopolysaccharideinduced inflammatory responses in microglial cells via p38 and nfkappab pathways / Int Immunopharmacol 50:14~21
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UCI(KEPA) : I410-ECN-0101-2019-510-000546396