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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 105 - 112 (8page)
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The present study investigated an ethanol extract (SSB) of a mixture of three medicinal plants of Vitisamurensis, Aralia cordata, and Glycyrrhizae radix for possible neuroprotective effects on neurotoxicity induced byAmyloid β protein (Aβ) (25-35) in cultured rat cortical neurons and antidementia activity in mice. Exposure of cultured corticalneurons to 15 μM Aβ (25-35) for 36 h induced neuronal apoptotic death. At 1-30㎍/㎖, SSB inhibited neuronal death,elevation of intracellular calcium concentration ([Ca2+]i), and generation of reactive oxygen species (ROS) induced by Aβ(25-35) in cultured cortical neurons. Memory impairment and increase of acetylcholinesterase activity induced by intracerebroventricularinjection of mice with 16 nmol Aβ (25-35) was inhibited by chronic treatment with SSB (25, 50 and100 ㎎/㎏, p.o., for 8 days). From these results, it is suggested that antidementia effect of SSB is due to its neuroprotectiveeffect against Aβ (25-35)-induced neurotoxicity and that SSB may have a therapeutic role in preventing the progression ofAlzheimer’s disease.
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참고문헌 (43)
참고문헌 신청
Alkam T / 2007 / A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Abeta(25-35) / Behavioural Brain Research 180:139~145
Atack JR / 1983 / Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type : Selective loss of the intermediate(10S)form / Neuroscience Letters 40:199~204
Bae K. / 2000 / The medicinal plants of Korea / Kyo-Hak Publishing Co :362~363
Ban JY / 2006 / Catechin and epicatechin from Smilacis chinae rhizome protect cultured rat cortical neurons against amyloid beta protein(25-35)-induced neurotoxicity through inhibition of cytosolic calcium elevation / Life Sciences 79:2251~2259
Butterfield DA / 2001 / Evidence of oxidative damage in Alzheimer's disease brain : Central role for amyloid beta-peptide / Trends in Molecular Medicine 7:548~554
Atack JR / 1983 / Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type : Selective loss of the intermediate(10S)form / Neuroscience Letters 40:199~204
Bae K. / 2000 / The medicinal plants of Korea / Kyo-Hak Publishing Co :362~363
Ban JY / 2006 / Catechin and epicatechin from Smilacis chinae rhizome protect cultured rat cortical neurons against amyloid beta protein(25-35)-induced neurotoxicity through inhibition of cytosolic calcium elevation / Life Sciences 79:2251~2259
Butterfield DA / 2001 / Evidence of oxidative damage in Alzheimer's disease brain : Central role for amyloid beta-peptide / Trends in Molecular Medicine 7:548~554
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