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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 177 - 187 (11page)
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We compared effects of fruit, leaf, and stem extracts from black raspberry on improvement of cholesterol andblood pressure in HepG2 and HUVEC cells, respectively. Cholesterol secretion was inhibited by water extracts of unripefruit and stem, but not leaf of black raspberry in HepG2 cells. Also, water extracts of unripe fruit, leaf, and stem reducedHMG-CoA reductase activity. Furthermore, nitric oxide production and expression of angiotensin-converting enzyme(ACE) protein were regulated by extracts of fruit, leaf, and stem of black raspberry in HUVEC cells. Overall, the rank orderaccording to the improving level of cholesterol and hypertension is as follows: stem > fruit > leaf. In addition, variouspolyphenol compounds displayed inhibitory effects of HMG-CoA reductase activity and ACE expression. Thus, these datasuggested that leaf and stem as wells as fruit of black raspberry can be used as useful food resources for reduction of cholesteroland blood pressure.
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참고문헌 (43)
참고문헌 신청
Aiello RJ / 2003 / ABCA1-deficient mice : Insights into the role of monocyte lipid efflux in HDL formation and inflammation / Arteriosclerosis Thrombosis and Vascular Biology 23:972~980
Atlas SA. / 2007 / The reninangiotensin aldosterone system : Pathophysiological role and pharmacologic inhibition / Journal of Managed Care Pharmacy 13:9~20
Bradford MM. / 1976 / Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Analytical Biochemistry 72:248~254
Brown MS / 1997 / The SREBP pathway : Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor / Cell 89:331~340
Brundert M / 2006 / Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI / Journal of Lipid Research 47:2408~2421
Atlas SA. / 2007 / The reninangiotensin aldosterone system : Pathophysiological role and pharmacologic inhibition / Journal of Managed Care Pharmacy 13:9~20
Bradford MM. / 1976 / Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Analytical Biochemistry 72:248~254
Brown MS / 1997 / The SREBP pathway : Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor / Cell 89:331~340
Brundert M / 2006 / Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI / Journal of Lipid Research 47:2408~2421
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UCI(KEPA) : I410-ECN-0101-2019-480-000587698