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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.10
- 수록면
- 369 - 377 (9page)
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In order to find out anticancer activity of Korean pepper (Capsicum annuum L.), the cytotoxicity against 8cell lines including 293 (normal kidney cells) and A-431 (epidermoid carcinoma cells) of extracts by extraction solvents andplant parts were investigated using MTT assay. Also the correlation between content of capsaicin known as anticanceringredient and cytotoxicity of extracts from pepper were analyzed. The distilled water extracts from seed and germinatedseed showed very high cytotoxicity against 6 cancer cell lines including A549 (lung carcinoma cells), AGS (stomach adenocarcinomacells), HeLa (cervix adenocarcinoma cells), HepG2 (hepatoblastoma cells), HT-29 (colon adenocarcinoma cells),and MCF-7 (breast adenocarcinoma cells). But 80% ethanol and methanol extracts showed cytotoxicity against 293 andAGS. The RC<sub>50</sub>, that was, the concentration of sample required for 50% reduction of cell viability, of seed and germinatedseed extracts against AGS were 33.4 ~ 389.1㎍/㎖ and 63.9 ~ 1,316.7㎍/㎖, respectively, so anticancer activity was higher inseed than in germinated seed. In capsaicin contents, seed with high cytotoxicity and pericarp with a little cytotoxicity contained47.4 ~ 1,260.0㎍/g and 58.3 ~ 1,498.0㎍/g, respectively. As these results, the correlation was not between cytotoxicityand capsaicin content.
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참고문헌 (32)
참고문헌 신청
Ana GC / 2006 / Determination of capsaicin and dihydrocapsaicin in Capsicum fruits by liquid chromatograhy-electrospray/time-offlight mass spectrometry / Journal of Agricultural Food Chemistry 54:9303~9311
Erin N / 2006 / Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells / Breastcancer Research and Treatment 99:351~364
Galvez AF / 1999 / A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells / Nature Biotechnology 17:495~500
강현민 / 2008 / 고추와 Capsaicin의 항산화 효능 비교 / Journal of Pharmacopuncture 11(1):109~118
Huang SP / 2009 / Capsaicin-induced apoptosis in human hepatma HepG2 cells / Anticancer Research 29:165~174
Erin N / 2006 / Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells / Breastcancer Research and Treatment 99:351~364
Galvez AF / 1999 / A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells / Nature Biotechnology 17:495~500
강현민 / 2008 / 고추와 Capsaicin의 항산화 효능 비교 / Journal of Pharmacopuncture 11(1):109~118
Huang SP / 2009 / Capsaicin-induced apoptosis in human hepatma HepG2 cells / Anticancer Research 29:165~174
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UCI(KEPA) : I410-ECN-0101-2019-480-000588059