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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 136 - 142 (7page)
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Background: Agrimonia pilosa Ledeb has been used as a traditional medicine for the treatment of hematuresis and uterine bleeding in Korea. It has been reported to have anti-obesity, anti-diabetes and anti-inflammaotry effect by regulating the inflammatory signaling pathway. However, the preventive effect of Agrimonia pilosa Ledeb on gastritis has not been elucidated. Thus, in the present study, we evaluated the effects of the water extract of Agrimonia pilosa Ledeb (APW) using HCl/EtOH-induced gastritis rat models.
Method and Results: Gastritis was induced in rats by HCl/EtOH administration. The rats in each group were orally administered with two doses of APW (100 and 500㎎/㎏). Omeprazole was used as a positive control drug. An enzyme-linked immunosorbent assay (ELISA) was used to measure the prostaglandin E2 (PGE2) levels in stomach. The treatment with 500㎎/㎏ APW reduced the gastric ulcer area. The APW treatment prevented a decreased in PGE2 concentration induced by HCl/EtOH in rats. In the micronucleus test, the ratio of micronucleated polychromatic erythrocytes to polychromatic erythrocytes showed no significant change in the APW-treated group compared with the control group.
Conclusions: These results indicate that APW could be used to prevent the gastritis caused by the HCl/EtOH-induced damage to stomach lining. In addition, the APW treatment showed no significant change in results of the micronucleus test. However, further experiments are required to determine how APW influenced the secretion of mucus and gastric acid using the chromosome aberration test and bacterial reverse mutation assay.
Method and Results: Gastritis was induced in rats by HCl/EtOH administration. The rats in each group were orally administered with two doses of APW (100 and 500㎎/㎏). Omeprazole was used as a positive control drug. An enzyme-linked immunosorbent assay (ELISA) was used to measure the prostaglandin E2 (PGE2) levels in stomach. The treatment with 500㎎/㎏ APW reduced the gastric ulcer area. The APW treatment prevented a decreased in PGE2 concentration induced by HCl/EtOH in rats. In the micronucleus test, the ratio of micronucleated polychromatic erythrocytes to polychromatic erythrocytes showed no significant change in the APW-treated group compared with the control group.
Conclusions: These results indicate that APW could be used to prevent the gastritis caused by the HCl/EtOH-induced damage to stomach lining. In addition, the APW treatment showed no significant change in results of the micronucleus test. However, further experiments are required to determine how APW influenced the secretion of mucus and gastric acid using the chromosome aberration test and bacterial reverse mutation assay.
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ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCE
참고문헌 (36)
참고문헌 신청
배지현 / 2005 / 선학초 추출물이 식중독 유발세균의 증식에 미치는 영향 / Journal of Nutrition and Health 38(2):112~116
Chew CS / 1993 / Intracellular mechanisms in control of acid secretion / Current Opinion in Gastroenterology 7:856~862
최원식 / 2012 / Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats / 한국산학기술학회논문지 13(4):1769~1776
Glickman JN / 2001 / Gastritis / Gastrointestinal Endoscopy Clinics of North America 11:717~740
Hoshino T / 2003 / Prostaglandin E2 protects gastric mucosal cells from apoptosis via EP2 and EP4 receptor activation / Journal of Biological Chemistry 278:12752~12758
Chew CS / 1993 / Intracellular mechanisms in control of acid secretion / Current Opinion in Gastroenterology 7:856~862
최원식 / 2012 / Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats / 한국산학기술학회논문지 13(4):1769~1776
Glickman JN / 2001 / Gastritis / Gastrointestinal Endoscopy Clinics of North America 11:717~740
Hoshino T / 2003 / Prostaglandin E2 protects gastric mucosal cells from apoptosis via EP2 and EP4 receptor activation / Journal of Biological Chemistry 278:12752~12758
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UCI(KEPA) : I410-ECN-0101-2019-480-000803855