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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 168 - 175 (8page)
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초록· 키워드
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Purpose: Barely sprout is a well-known oriental herbal medicine with a wide range of health benefits. Recent studies have provided scientific evidence of its therapeutic effects with expanded application. This study investigated anti-melanogenic effect of barley sprout water extract (BSE) in murine melanocyte B16F10. Methods: Various concentrations (0, 50, 125, and 250 ㎍/mL) of BSE and arbutin (150 ppm) were applied to B16F10 stimulated with or without alpha-melanocyte stimulating hormone (100 nM) for 72 hours. The whitening potency of BSE was determined altered cellular melanin contents. Activity and expression of tyrosinase and microphthalmia-associated transcription factor (MITF) were also assayed. Results: Experimental results revealed that treatment with BSE reduced cellular melanin production by approximately 40% compared to the control. Molecular findings supported that suppressed activity and expression of tyrosinase and MITF proteins by BSE were associated with declined cellular melanogenesis. Furthermore, anti-melanogenic effect of BSE (250 ㎍/mL) was similar to that of arbutin, a commonly used whitening agent. Lastly, polyphenols including p-coumaric, ferulic, and vanillic acids were identified in BSE using HPLC analyses. They might be potential active ingredients showing such melanogenesis-reducing effect. Conclusion: BSE was evident to possess favorable anti-melanogenic potency in an in vitro model. As a natural food sourced material, BSE could be an effective depigmentation agent with potential application in pharmaceutical and cosmetic industries.
목차
ABSTRACT
Introduction
Methods
Results
Discussion
Summary
References
참고문헌 (26)
참고문헌 신청
Lin JW / 2008 / Natural products with skin-whitening effects / J Food Drug Anal 16(2):1~10
Pillaiyar T / 2017 / Recent development of signaling pathways inhibitors of melanogenesis / Cell Signal 40:99~115
Liu-Smith F / 2016 / Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma / Mol Nutr Food Res 60(6):1264~1274
심유진 / 2017 / Inhibitory effect of Gastrodia elata Blume extract on alpha-melanocyte stimulating hormone-induced melanogenesis in murine B16F10 melanoma / Nutrition Research and Practice 11(3):173~179
Chen WC / 2015 / Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling / Sci Rep 5(1):7995
Pillaiyar T / 2017 / Recent development of signaling pathways inhibitors of melanogenesis / Cell Signal 40:99~115
Liu-Smith F / 2016 / Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma / Mol Nutr Food Res 60(6):1264~1274
심유진 / 2017 / Inhibitory effect of Gastrodia elata Blume extract on alpha-melanocyte stimulating hormone-induced melanogenesis in murine B16F10 melanoma / Nutrition Research and Practice 11(3):173~179
Chen WC / 2015 / Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling / Sci Rep 5(1):7995
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UCI(KEPA) : I410-ECN-0101-2019-594-000768169